Neonatal engraftment by oligodendrocyte progenitor cells (OPCs) permits the myelination of
the congenitally dysmyelinated brain. To establish a potential autologous source of these …

Congenitally hypomyelinated shiverer mice fail to generate compact myelin and die by 18–21
weeks of age. Using multifocal anterior and posterior fossa delivery of sorted fetal human …

In this study, we investigated whether intrinsic glial dysfunction contributes to the pathogenesis
of schizophrenia (SCZ). Our approach was to establish humanized glial chimeric mice …

Experimental animals with myelin disorders can be treated by transplanting oligodendrocyte
progenitor cells (OPCs) into the affected brain or spinal cord. OPCs have been isolated by …

Neonatally transplanted human glial progenitor cells (hGPCs) densely engraft and myelinate
the hypomyelinated shiverer mouse. We found that, in hGPC-xenografted mice, the human …

Competition among adult brain cells has not been extensively researched. To investigate
whether healthy glia can outcompete diseased human glia in the adult forebrain, we engrafted …

Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease triggered by
infection with the human gliotropic JC virus (JCV). Due to the human-selective nature of the …

Neonatally transplanted human glial progenitor cells (hGPCs) can myelinate the brains of
myelin-deficient shiverer mice, rescuing their phenotype and survival. Yet, it has been unclear …

Genomic analyses have revealed heterogeneity among glial progenitor cells (GPCs), but
the compartment selectivity of human GPCs (hGPCs) is unclear. Here, we asked if GPCs of …

The pediatric leukodystrophies comprise a category of disease manifested by neonatal or
childhood deficiencies in myelin production or maintenance; these may be due to hereditary …