Across the eukaryotic phylogeny, offspring usually inherit their mitochondrial genome from
only one of two parents: in animals, the female. Although mechanisms that eliminate …

10.7554/eLife.08469.001 Previously, we described a large collection of Minos-Mediated
Integration Cassettes (MiMICs) that contain two phiC31 recombinase target sites and allow the …

High copy number and random segregation confound genetic analysis of the mitochondrial
genome. We developed an efficient selection for heritable mitochondrial genome (mtDNA) …

Cse4p is an essential histone H3 variant in Saccharomyces cerevisiae that defines
centromere identity and is required for proper segregation of chromosomes. In this study, we …

Using the yeast GAL4 transcription factor to control expression in Drosophila melanogaster
has long been ineffective in female germ cells during oogenesis. Here, DeLuca and …

Polycomb silencing represses gene expression and provides a molecular memory of chromatin
state that is essential for animal development. We show that Drosophila female germline …

Mitochondrial DNA (mtDNA) is typically inherited from only one parent [1–3]. In animals, this
is usually the mother. Maternal inheritance is often presented as the passive outcome of the …

Background Cells control progression through late mitosis by regulating Cdc20 and Cdh1,
the two mitotic activators of the anaphase-promoting complex (APC). The control of Cdc20 …

The synaptonemal complex (SC) is a proteinaceous scaffold that is assembled between paired
homologous chromosomes during the onset of meiosis. Timely expression of SC coding …

Polycomb silencing represses gene expression and provides a molecular memory of chromatin
state that is essential for animal development. We show that Drosophila female germline …