Genome-wide analysis of DNA methylation has now become a relatively inexpensive
technique thanks to array-based methylation profiling technologies. The recently developed …

Background Genome-wide DNA methylation (DNAm) profiling has allowed for the development
of molecular predictors for a multitude of traits and diseases. Such predictors may be …

The main clinical feature of bipolar affective disorder is a change of mood to depression or
elation. Unipolar disorder, also termed majc depressive disorder, describes the occurrence c …

Introduction The “epigenetic clock” is a DNA methylation–based estimate of biological age
and is correlated with chronological age—the greatest risk factor for Alzheimer's disease (AD)…

Inflammatory processes are implicated in the aetiology of Major Depressive Disorder (MDD);
however, the relationship between peripheral inflammation, brain structure and depression …

'Epigenetic age acceleration' is a valuable biomarker of ageing, predictive of morbidity and
mortality, but for which the underlying biological mechanisms are not well established. Two …

Background Multiple studies have made robust associations between differential DNA
methylation and exposure to cigarette smoke. But whether a DNA methylation phenotype is …

Alcohol misuse is common in many societies worldwide and is associated with extensive
morbidity and mortality, often leading to alcohol use disorders (AUD) and alcohol-related end-…

Variation in DNA methylation (DNAm) is associated with lifestyle factors such as smoking
and body mass index (BMI) but there has been little research exploring its ability to identify …

Background Advanced age is associated with cognitive and physical decline and is a major
risk factor for a multitude of disorders. There is also a gap in life expectancy between males …