We present a database of copy number variations (CNVs) detected in 2026 disease-free
individuals, using high-density, SNP-based oligonucleotide microarrays. This large cohort, …

It has long been known that there is a genetic component to obesity, and that characterizing
this underlying factor would likely offer the possibility of better intervention in the future. …

We have previously reported suggestive linkage of type 2 diabetes mellitus to chromosome
10q 1 . We genotyped 228 microsatellite markers in Icelandic individuals with type 2 …

Comprehensive identification and cataloging of copy number variations (CNVs) is required
to provide a complete view of human genetic variation. The resolution of CNV detection in …

Autism spectrum disorders (ASDs) are childhood neurodevelopmental disorders with complex
genetic origins 1 , 2 , 3 , 4 . Previous studies focusing on candidate genes or genomic …

Obesity among children and adults has notably escalated over recent decades and represents
a global major health problem. We now know that both genetic and environmental factors …

We mapped a gene predisposing to myocardial infarction to a locus on chromosome 13q12–13.
A four-marker single-nucleotide polymorphism (SNP) haplotype in this locus spanning …

Autism spectrum disorders (ASDs) represent a group of childhood neurodevelopmental and
neuropsychiatric disorders characterized by deficits in verbal communication, impairment of …

Osteoporosis is a common disease with a strong genetic component 1–3 , characterized by
reduced bone mass and increased fracture risk 4 . Current evidence suggests that the …

Type 1 diabetes (T1D) in children results from autoimmune destruction of pancreatic beta
cells, leading to insufficient production of insulin 1 . A number of genetic determinants of T1D …