Establishment and maintenance of the blood system relies on self-renewing hematopoietic
stem cells (HSCs) that normally reside in small numbers in the bone marrow niche of adult …

The laboratory mouse shares the majority of its protein-coding genes with humans, making
it the premier model organism in biomedical research, yet the two mammals differ in …

THE zinc-finger transcription factor GATA-1 (previously known as GF-1, NF-E1 or Eryf 1 (refs
1-5)) binds to GATA consensus elements in regulatory regions of theα- and β-globin gene …

Blood cell development relies on the expansion and maintenance of haematopoietic stem
and progenitor cells in the embryo. By gene targeting in mouse embryonic stem cells, we …

CYTOGENETIC analysis has identified chromosome Ilpl3 as the smallest overlap region for
deletions found in individuals with WAGR syndrome, which includes Wilms tumour (a …

Single-cell RNA sequencing (scRNA-seq) technologies are poised to reshape the current
cell-type classification system. However, a transcriptome-based single-cell atlas has not been …

Much attention has focused on a small set of transcription factors that maintain human or mouse
embryonic stem (ES) cells in a pluripotent state. To gain a more complete understanding …

Haematopoietic stem cell (HSC) homeostasis is tightly controlled by growth factors, signalling
molecules and transcription factors. Definitive HSCs derived during embryogenesis in the …

Embryonic stem (ES) cells are pluripotent 1 , 2 and of therapeutic potential in regenerative
medicine 3 , 4 . Understanding pluripotency at the molecular level should illuminate …

CHROMOSOMAL translocations associated with malignancies often result in deregulated
expression of genes encoding transcription factors 1 . In human T-cell leukaemias such …