Background: We characterized RNA transcript levels for the whole Drosophila genome
during normal aging. We compared age-dependent profiles from animals aged under full-nutrient …

Genetic dissection of complex, polygenic trait variation is a key goal of medical and
evolutionary genetics. Attempts to identify genetic variants underlying complex traits have been …

The Drosophila Synthetic Population Resource (DSPR) is a newly developed multifounder
advanced intercross panel consisting of >1600 recombinant inbred lines (RILs) designed for …

It has been hypothesized that individually-rare hidden structural variants (SVs) could account
for a significant fraction of variation in complex traits. Here we identified more than 20,000 …

Here we present computational machinery to efficiently and accurately identify transposable
element (TE) insertions in 146 next-generation sequenced inbred strains of Drosophila …

Association studies are widely seen as the most promising approach for finding polymorphisms
that influence genetically complex traits, such as common diseases and responses to …

Herpes simplex virus type 1 (HSV-1) strain KOS has been extensively used in many studies
to examine HSV-1 replication, gene expression, and pathogenesis. Notably, strain KOS is …

For most complex traits we have a poor understanding of the positions, phenotypic effects,
and population frequencies of the underlying genetic variants contributing to their variation. …

A quantitative trait locus (QTL) genetic analysis of morphological and reproductive traits
distinguishing the sibling species Drosophila simulans and D. sechellia was carried out in a …

Modern genetic mapping is plagued by the “missing heritability” problem, which refers to the
discordance between the estimated heritabilities of quantitative traits and the variance …