Characterization of human monocyte subsets by whole blood flow cytometry analysis
R Marimuthu, H Francis, S Dervish, SCH Li… - JoVE (Journal of …, 2018 - jove.com
Monocytes are key contributors in various inflammatory disorders and alterations to these
cells, including their subset proportions and functions, can have pathological significance. An …
cells, including their subset proportions and functions, can have pathological significance. An …
[HTML][HTML] Activated protein C enhances human keratinocyte barrier integrity via sequential activation of epidermal growth factor receptor and Tie2
M Xue, SO Chow, S Dervish, YKA Chan… - Journal of biological …, 2011 - ASBMB
Keratinocytes play a critical role in maintaining epidermal barrier function. Activated protein
C (APC), a natural anticoagulant with anti-inflammatory and endothelial barrier protective …
C (APC), a natural anticoagulant with anti-inflammatory and endothelial barrier protective …
[HTML][HTML] Pharmacologic targeting of renal ischemia-reperfusion injury using a normothermic machine perfusion platform
…, NT Zanjani, CH P'ng, D Meijles, S Dervish… - Scientific Reports, 2020 - nature.com
Normothermic machine perfusion (NMP) is an emerging modality for kidney preservation
prior to transplantation. NMP may allow directed pharmacomodulation of renal ischemia-…
prior to transplantation. NMP may allow directed pharmacomodulation of renal ischemia-…
[PDF][PDF] Core liver homeostatic co-expression networks are preserved but respond to perturbations in an organism-and disease-specific manner
…, M Ramezani-Moghadam, V Ho, D Dvorkin, S Dervish… - Cell Systems, 2021 - cell.com
Findings about chronic complex diseases are difficult to extrapolate from animal models to
humans. We reason that organs may have core network modules that are preserved between …
humans. We reason that organs may have core network modules that are preserved between …
[HTML][HTML] Protease activated receptor-2 mediates activated protein c–induced cutaneous wound healing via inhibition of p38
Activated protein C (APC) is a natural anticoagulant that exerts anti-inflammatory and
cytoprotective properties mediated through the protease activated receptor (PAR)-1. APC can also …
cytoprotective properties mediated through the protease activated receptor (PAR)-1. APC can also …
[HTML][HTML] Plasmacytoid dendritic cells have divergent effects on HIV infection of initial target cells and induce a pro-retention phenotype
…, H Rana, B Johnson, N Popovic, S Dervish… - PLoS …, 2021 - journals.plos.org
Although HIV infection inhibits interferon responses in its target cells in vitro, interferon
signatures can be detected in vivo soon after sexual transmission, mainly attributed to …
signatures can be detected in vivo soon after sexual transmission, mainly attributed to …
Protease‐activated receptor 2, rather than protease‐activated receptor 1, contributes to the aggressive properties of synovial fibroblasts in rheumatoid arthritis
M Xue, YKA Chan, K Shen, S Dervish… - Arthritis & …, 2012 - Wiley Online Library
Objective To investigate whether protease‐activated receptor 1 (PAR‐1) and/or PAR‐2
promotes the invasiveness/proliferation of synovial fibroblasts (SFs) and to determine the …
promotes the invasiveness/proliferation of synovial fibroblasts (SFs) and to determine the …
[HTML][HTML] Standardisation of flow cytometry for whole blood immunophenotyping of islet transplant and transplant clinical trial recipients
…, L Williams, K Keung, NT Zanjani, S Dervish… - PLoS …, 2019 - journals.plos.org
Understanding the immunological phenotype of transplant recipients is important to improve
outcomes and develop new therapies. Immunophenotyping of whole peripheral blood (WPB…
outcomes and develop new therapies. Immunophenotyping of whole peripheral blood (WPB…
[HTML][HTML] Activated protein C inhibits pancreatic islet inflammation, stimulates T regulatory cells, and prevents diabetes in non-obese diabetic (NOD) mice
M Xue, S Dervish, LC Harrison, G Fulcher… - Journal of Biological …, 2012 - ASBMB
Activated protein C (aPC) is a natural anticoagulant with strong cyto-protective and anti-inflammatory
properties. aPC inhibits pancreatic inflammation and preserves functional islets …
properties. aPC inhibits pancreatic inflammation and preserves functional islets …
Activated protein C targets immune cells and rheumatoid synovial fibroblasts to prevent inflammatory arthritis in mice
Objectives To investigate whether activated protein C (APC), a physiological anticoagulant
can inhibit the inflammatory/invasive properties of immune cells and rheumatoid arthritis …
can inhibit the inflammatory/invasive properties of immune cells and rheumatoid arthritis …