SARS-CoV-2 is a novel coronavirus that emerged in 2019 and is causing the COVID-19
pandemic. There is no current standard of care. Clinicians need to be mindful of the toxicity of a …

SARS-CoV-2 emerged in December 2019 and led to the COVID-19 pandemic. Efforts to
develop therapeutics have led to innovations such as mRNA vaccines and oral antivirals. Here …

Cystectomy is a standard treatment for muscle-invasive bladder cancer (MIBC), but it is life-altering.
We initiated a phase 2 study in which patients with MIBC received four cycles of …

Menopause is associated with bone loss and enhanced visceral adiposity. A polyclonal
antibody that targets the β-subunit of the pituitary hormone follicle-stimulating hormone (Fsh) …

Prostate cancer (PCa) preferentially metastasizes to bone, leading to complications including
severe pain, fractures, spinal cord compression, bone marrow suppression, and a mortality …

Programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1)-blockade
immunotherapies have limited efficacy in the treatment of bladder cancer. Here, we show that …

Targeted cancer therapies, which act on specific cancer-associated molecular targets, are
predominantly inhibitors of oncogenic kinases. While these drugs have achieved some …

Kinase inhibitor resistance constitutes a major unresolved clinical challenge in cancer.
Furthermore, the role of serine/threonine phosphatase deregulation as a potential cause for …

Impairment of protein phosphatases, including the family of serine/threonine phosphatases
designated PP2A, is essential for the pathogenesis of many diseases, including cancer. The …

Coagulation factor XII (FXII) deficiency is associated with decreased neutrophil migration,
but the mechanisms remain uncharacterized. Here, we examine how FXII contributes to the …