Background In cross-sectional studies, elevated plasma homocysteine levels have been
associated with poor cognition and dementia. Studies of newly diagnosed dementia are …

Blood pressure is a heritable trait 1 influenced by several biological pathways and responsive
to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm …

Background and Purpose— This scientific statement provides an overview of the evidence
on vascular contributions to cognitive impairment and dementia. Vascular contributions to …

INTRODUCTION Brain disorders may exhibit shared symptoms and substantial epidemiological
comorbidity, inciting debate about their etiologic overlap. However, detailed study of …

Dementia is an increasing focus for policymakers, civil organizations and multidisciplinary
researchers. The most recent descriptive epidemiological research into dementia is enabling …

ContextThe long-term risk for developing hypertension is best described by the lifetime risk
statistic. The lifetime risk for hypertension and trends in this risk over time are unknown.…

We sought to identify new susceptibility loci for Alzheimer's disease through a staged
association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease …

Background Comprehensive long-term data on atrial fibrillation trends in men and women
are scant. We aimed to provide such data through analysis of the Framingham cohort over 50 …

Context Genome-wide association studies (GWAS) have recently identified CLU, PICALM,
and CR1 as novel genes for late-onset Alzheimer disease (AD). Objectives To identify and …

The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic
architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of …