Pancreatic β cells adapt to compensate for increased metabolic demand during insulin
resistance. Although the microRNA pathway has an essential role in β cell proliferation, the …

In response to fasting or hyperglycemia, the pancreatic β-cell alters its output of secreted
insulin; however, the pathways governing this adaptive response are not entirely established. …

miR-184 is a highly evolutionary conserved microRNA (miRNA) from fly to human. The
importance of miR-184 was underscored by the discovery that point mutations in miR-184 gene …

Argonaute2 (Ago2) is an established component of the microRNA-induced silencing
complex. Similar to miR-375 loss-of-function studies, inhibition of Ago2 in the pancreatic β-cell …

Background To date, numerous nucleic acid species have been detected in the systemic
circulation including microRNAs (miRNAs); however, their functional role in this compartment …

Max delbrueck Center for Molecular Medicine; Berlin, Germany www. landesbioscience. com
Cell Cycle 1217 direct targets of the miRNAs and their biological significance remains to …

miR-184 is a highly evolutionary conserved microRNA (miRNA) from fly to human. The
importance of miR-184 was underscored by the discovery that point mutations in miR-184 gene …

For more than 100 years, the fruit fly Drosophila melanogaster has been one of the most
studied model organisms. Here, we present a single-cell atlas of the adult fly, Tabula …

Drosophila blood cells, called hemocytes, are classified into plasmatocytes, crystal cells, and
lamellocytes based on the expression of a few marker genes and cell morphologies, which …

Studies of the adult Drosophila midgut have led to many insights in our understanding of cell-type
diversity, stem cell regeneration, tissue homeostasis, and cell fate decision. Advances …