With fertilization, the paternal and maternal contributions to the zygote are not equal. The
oocyte and spermatozoon are equipped with complementary arsenals of cellular structures and …

The tightly condensed chromatin of spermatozoa is rapidly decondensed after the spermatozoa
enter oocytes. Although no factor involved in sperm chromatin decondensation (SCD) …

In many eukaryotes, condensins I and II associate with chromosomes in an ordered fashion
during mitosis and play nonoverlapping functions in their assembly and segregation. Here …

As predicted by the notion that sister chromatid cohesion is mediated by entrapment of sister
DNAs inside cohesin rings, there is perfect correlation between co-entrapment of circular …

Reconstitution of female germ cell development in vitro is a key challenge in reproductive
biology and medicine. We show here that female (XX) embryonic stem cells and induced …

Our understanding of the signalling pathways regulating early human development is limited,
despite their fundamental biological importance. Here, we mine transcriptomics datasets to …

Protection of peri-centromeric (periCEN) REC8 cohesin from Separase and sister
kinetochore (KT) attachment to microtubules emanating from the same spindle pole (co-orientation) …

During oocyte growth in the ovary, the nucleolus is mainly responsible for ribosome biogenesis.
However, in the fully-grown oocyte, all transcription ceases, including ribosomal RNA …

The mammalian oocyte nucleolus, the most prominent subcellular organelle in the oocyte,
is vital in early development, yet its key functions and constituents remain unclear. We show …

Chromosome separation in meiosis I is different from those in mitosis and meiosis II inthat
homologs separate from each other in the former while sisters do so in the latter. Weshow here …