The cellular NADH/NAD + ratio is fundamental to biochemistry, but the extent to which it
reflects versus drives metabolic physiology in vivo is poorly understood. Here we report the in …

Scope Ginger exerts protective effects on obesity and its complications. Our objectives here
are to identify bioactive compounds that inhibit adipogenesis and lipid accumulation in vitro, …

Accumulating evidence suggests that subcutaneous and visceral adipose tissues are
differentially associated with metabolic disorders. In obesity, subcutaneous adipose tissue is …

Z ingiber officinale R oscoe, one of the most widely used spices, has been reported to have
anti‐obesity and anti‐diabetes effects. In the present study, we investigated the effects of 6‐…

Insulin receptor (Insr) protein is present at higher levels in pancreatic β-cells than in most other
tissues, but the consequences of β-cell insulin resistance remain enigmatic. Here, we use …

Background CEACAM1 regulates insulin sensitivity by promoting insulin clearance. Accordingly,
global C57BL/6J.Cc1 −/− null mice display hyperinsulinemia due to impaired insulin …

A decrease in ovarian estrogens in postmenopausal women increases the risk of weight gain,
cardiovascular disease, type 2 diabetes, and chronic inflammation. While it is known that …

Obesity-mediated inflammation is a major cause of insulin resistance, and macrophages
play an important role in this process. The 78-kDa glucose-regulated protein (GRP78) is a …

Increasing evidence shows a potential link between the perinatal nutrient environment and
metabolic outcome in offspring. Here, we investigated the effects of maternal feeding of a high…

Soy isoflavones, particularly genistein, have been shown to exhibit anti-obesity effects.
When compared with the isoflavones genistin, daidzin, coumestrol, genistein, daidzein, 6-o-…