[HTML][HTML] NetMHCpan, a Method for Quantitative Predictions of Peptide Binding to Any HLA-A and -B Locus Protein of Known Sequence
…, T Blicher, K Lamberth, M Harndahl, S Justesen… - PloS one, 2007 - journals.plos.org
Background Binding of peptides to Major Histocompatibility Complex (MHC) molecules is
the single most selective step in the recognition of pathogens by the cellular immune system. …
the single most selective step in the recognition of pathogens by the cellular immune system. …
Phenotype, specificity and avidity of antitumour CD8+ T cells in melanoma
…, KR Clauser, SA Shukla, D Neuberg, S Justesen… - Nature, 2021 - nature.com
Interactions between T cell receptors (TCRs) and their cognate tumour antigens are central
to antitumour immune responses 1 , 2 – 3 ; however, the relationship between phenotypic …
to antitumour immune responses 1 , 2 – 3 ; however, the relationship between phenotypic …
[HTML][HTML] Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers
PD-1 blockade unleashes CD8 T cells 1 , including those specific for mutation-associated
neoantigens (MANA), but factors in the tumour microenvironment can inhibit these T cell …
neoantigens (MANA), but factors in the tumour microenvironment can inhibit these T cell …
[HTML][HTML] A vaccine targeting mutant IDH1 in newly diagnosed glioma
Mutated isocitrate dehydrogenase 1 (IDH1) defines a molecularly distinct subtype of diffuse
glioma 1 , 2 – 3 . The most common IDH1 mutation in gliomas affects codon 132 and …
glioma 1 , 2 – 3 . The most common IDH1 mutation in gliomas affects codon 132 and …
A large peptidome dataset improves HLA class I epitope prediction across most of the human population
…, T Ouspenskaia, T Law, S Justesen… - Nature …, 2020 - nature.com
Prediction of HLA epitopes is important for the development of cancer immunotherapies and
vaccines. However, current prediction algorithms have limited predictive power, in part …
vaccines. However, current prediction algorithms have limited predictive power, in part …
Definition of supertypes for HLA molecules using clustering of specificity matrices
…, C Sylvester-Hvid, K Lamberth, G Røder, S Justesen… - Immunogenetics, 2004 - Springer
Major histocompatibility complex (MHC) proteins are encoded by extremely polymorphic genes
and play a crucial role in immunity. However, not all genetically different MHC molecules …
and play a crucial role in immunity. However, not all genetically different MHC molecules …
[HTML][HTML] Quantitative predictions of peptide binding to any HLA-DR molecule of known sequence: NetMHCIIpan
CD4 positive T helper cells control many aspects of specific immunity. These cells are specific
for peptides derived from protein antigens and presented by molecules of the extremely …
for peptides derived from protein antigens and presented by molecules of the extremely …
A carbon nanotube–polymer composite for T-cell therapy
Clinical translation of cell therapies requires strategies that can manufacture cells efficiently
and economically. One promising way to reproducibly expand T cells for cancer therapy is …
and economically. One promising way to reproducibly expand T cells for cancer therapy is …
Unannotated proteins expand the MHC-I-restricted immunopeptidome in cancer
…, YT Chow, Z Ji, I Jungreis, SA Shukla, S Justesen… - Nature …, 2022 - nature.com
Tumor-associated epitopes presented on MHC-I that can activate the immune system against
cancer cells are typically identified from annotated protein-coding regions of the genome, …
cancer cells are typically identified from annotated protein-coding regions of the genome, …
[HTML][HTML] NetMHCIIpan-2.0 - Improved pan-specific HLA-DR predictions using a novel concurrent alignment and weight optimization training procedure
Background Binding of peptides to Major Histocompatibility class II (MHC-II) molecules play
a central role in governing responses of the adaptive immune system. MHC-II molecules …
a central role in governing responses of the adaptive immune system. MHC-II molecules …