Ependymal overexpression of brain-derived neurotrophic factor (BDNF) stimulates neuronal
addition to the adult striatum, from subependymal progenitor cells. Noggin, by suppressing …

This study was designed to investigate functional recovery after the transplantation of
mesenchymal stem cells (MSCs) or neurally differentiated MSCs (NMSCs) derived from bone …

DNA has not been utilized to record temporal information, although DNA has been used to
record biological information and to compute mathematical problems. Here, we found that …

The use of prime editing—a gene-editing technique that induces small genetic changes
without the need for donor DNA and without causing double strand breaks—to correct …

Zinc-finger nucleases (ZFNs) and TAL-effector nucleases (TALENs) are powerful tools for
creating genetic modifications in eukaryotic cells and organisms. But wild-type and mutant …

Several Streptococcus pyogenes Cas9 (SpCas9) variants have been developed to improve
an enzyme’s specificity or to alter or broaden its protospacer-adjacent motif (PAM) …

Hemophilia A, one of the most common genetic bleeding disorders, is caused by various
mutations in the blood coagulation factor VIII (F8) gene. Among the genotypes that result in …

Although prime editing is a promising genome editing method, the efficiency of prime editor
2 (PE2) is often insufficient. Here we generate a more efficient variant of PE2, named hyPE2, …

Biophysical cues can improve the direct reprogramming of fibroblasts into neurons that can
be used for therapeutic purposes. However, the effects of a three-dimensional (3D) …

The present study investigated the distribution and antimicrobial susceptibility patterns of
Vibrio parahaemolyticus in water samples and aquatic animals (fish and shrimp) from major …