Autophagy is a process of cellular self-digestion induced by various forms of starvation.
Although nitrogen deficit is a common trigger, some yeast cells induce autophagy upon switch …

Methionine and cysteine metabolisms are important for the survival and pathogenesis of
Mycobacterium tuberculosis (Mtb). The transsulfuration pathway converts methionine to …

10.7554/eLife.44795.001 Cells must appropriately sense and integrate multiple metabolic
resources to commit to proliferation. Here, we report that S. cerevisiae cells regulate carbon …

African sleeping sickness is a disease caused by Trypanosoma brucei. T. brucei proliferate
rapidly in the mammalian bloodstream as long, slender forms, but at higher population …

Protein translation is an energetically demanding process that must be regulated in response
to changes in nutrient availability. Herein, we report that intracellular methionine and …

Anabolic and catabolic signaling mediated via mTOR and AMPK (AMP-activated kinase)
have to be intrinsically coupled to mitochondrial functions for maintaining homeostasis and …

10.7554/eLife.13614.001 Many organisms, including species from all kingdoms of life, can
survive desiccation by entering a state with no detectable metabolism. To survive, C. elegans …

The inner mitochondrial membrane (IMM), housing components of the electron transport
chain (ETC), is the site for respiration. The ETC relies on mobile carriers; therefore, it has long …

The carbohydrate-response element-binding protein (ChREBP) is a glucose-responsive
transcription factor that plays an essential role in converting excess carbohydrate to fat storage …

Iron-sulfur (Fe-S) cluster proteins carry out essential cellular functions in diverse organisms,
including the human pathogen Mycobacterium tuberculosis (Mtb). The mechanisms …