Impact of PACAP and PAC1 receptor deficiency on the neurochemical and behavioral effects of acute and chronic restraint stress in male C57BL/6 mice

T Mustafa, SZ Jiang, AM Eiden, E Weihe… - Stress, 2015 - Taylor & Francis
Acute restraint stress (ARS) for 3 h causes corticosterone (CORT) elevation in venous blood,
which is accompanied by Fos up-regulation in the paraventricular nucleus (PVN) of male …

Schizophrenia-like dopamine release abnormalities in a mouse model of NMDA receptor hypofunction

K Nakao, V Jeevakumar, SZ Jiang, Y Fujita… - Schizophrenia …, 2019 - academic.oup.com
Amphetamine-induced augmentation of striatal dopamine and its blunted release in
prefrontal cortex (PFC) is a hallmark of schizophrenia pathophysiology. Although N-methyl-D-…

[HTML][HTML] Neuropsychiatric phenotypes produced by GABA reduction in mouse cortex and hippocampus

…, Y Fujita, AF Bartley, SZ Jiang… - …, 2018 - nature.com
Whereas cortical GAD67 reduction and subsequent GABA level decrease are consistently
observed in schizophrenia and depression, it remains unclear how these GABAergic …

Activation of the HPA axis and depression of feeding behavior induced by restraint stress are separately regulated by PACAPergic neurotransmission in the mouse

SZ Jiang, LE Eiden - Stress, 2016 - Taylor & Francis
We measured serum CORT elevation in wild-type and PACAP-deficient C57BL/6N male
mice after acute (1 h) or prolonged (2–3 h) daily restraint stress for 7 d. The PACAP …

[HTML][HTML] The guanine nucleotide exchange factor RapGEF2 is required for ERK-dependent immediate-early gene (Egr1) activation during fear memory formation

SZ Jiang, M Shahoha, HY Zhang… - Cellular and Molecular …, 2024 - Springer
The MAP kinase ERK is important for neuronal plasticity underlying associative learning, yet
specific molecular pathways for neuronal ERK activation are undetermined. RapGEF2 is a …

Cocaine-dependent acquisition of locomotor sensitization and conditioned place preference requires D1 dopaminergic signaling through a cyclic AMP, NCS-Rapgef2 …

SZ Jiang, S Sweat, SP Dahlke, K Loane… - Journal of …, 2021 - Soc Neuroscience
Elucidation of the mechanism of dopamine signaling to ERK that underlies plasticity in dopamine
D1 receptor-expressing neurons leading to acquired cocaine preference is incomplete. …

[HTML][HTML] What's new in endocrinology: the chromaffin cell

LE Eiden, SZ Jiang - Frontiers in Endocrinology, 2018 - frontiersin.org
Recent advances in understanding the intracellular and intercellular features of adrenal
chromatin cells as stress transducers are reviewed here, along with their implications for …

NCS-Rapgef2, the protein product of the neuronal Rapgef2 gene, is a specific activator of D1 dopamine receptor-dependent ERK phosphorylation in mouse brain

SZ Jiang, W Xu, AC Emery, CR Gerfen, MV Eiden… - eneuro, 2017 - eneuro.org
The neuritogenic cAMP sensor (NCS), encoded by the Rapgef2 gene, links cAMP elevation
to activation of extracellular signal-regulated kinase (ERK) in neurons and neuroendocrine …

[HTML][HTML] PACAP controls endocrine and behavioral stress responses via separate brain circuits

SZ Jiang, HY Zhang, LE Eiden - Biological Psychiatry Global Open Science, 2023 - Elsevier
Background The neuropeptide PACAP (pituitary adenylate cyclase-activating polypeptide) is
a master regulator of central and peripheral stress responses, yet it is not clear how PACAP …

Hippocampal cAMP-dependent synaptic potentiation, ERK-dependent immediate-early gene activation, and context-dependent fear conditioning in mice are linked …

SZ Jiang, M Shahoha, HA Tejeda, U Ashery, LE Eiden - bioRxiv, 2022 - biorxiv.org
The MAP kinase ERK is important for neuronal plasticity underlying associative learning, yet
specific molecular pathways for ERK activation in hippocampus are still largely …