Alzheimer's disease (AD) involves amyloid β (Aβ) accumulation, oxidative damage, and
inflammation, and risk is reduced with increased antioxidant and anti-inflammatory consumption. …

Insulin-degrading enzyme (IDE) is one of the proteins that has been demonstrated to play a
key role in degrading β-amyloid (Aβ) monomer in vitro and in vivo, raising the possibility of …

Although active and passive immunization against the β‐amyloid peptide (Aβ) of amyloid
plaque‐bearing transgenic mice markedly reduces amyloid plaque deposition and improves …

A functional genetic screen using loss-of-function and gain-of-function alleles was performed
to identify modifiers of tau-induced neurotoxicity using the 2N/4R (full-length) isoform of wild…

… Our work focuses on CUR’s … CUR’s anti-inflammatory and anti-oxidant actions may be useful
in the prevention-treatment of neurodegenerative diseases, eg Alzheimer’s and Parkinson’s …

About two-thirds of the vital genes in the Drosophila genome are involved in eye development,
making the fly eye an excellent genetic system to study cellular function and development…

Neurodegenerative diseases encompass a large group of neurological disorders. Clinical
symptoms can include memory loss, cognitive impairment, loss of movement or loss of control …

Background Heme oxygenase-1 (HO-1) is a critical cytoprotective enzyme that limits oxidative
stress, inflammation, and cellular injury within the central nervous system (CNS) and other …

Heme oxygenase-1 (HO-1) is a highly inducible and ubiquitous cellular enzyme that subserves
cytoprotective responses to toxic insults, including inflammation and oxidative stress. In …

Null mutations in the genes white and brown, but not scarlet, enhance a rough eye phenotype
in a Drosophila melanogaster model of tauopathy; however, adding rosy mutations …