[HTML][HTML] Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential
The stem cells that maintain and repair the postnatal skeleton remain undefined. One model
suggests that perisinusoidal mesenchymal stem cells (MSCs) give rise to osteoblasts, …
suggests that perisinusoidal mesenchymal stem cells (MSCs) give rise to osteoblasts, …
Denervation suppresses gastric tumorigenesis
…, Y Hayakawa, Y Kodama, S Muthupalani… - Science translational …, 2014 - science.org
The nervous system plays an important role in the regulation of epithelial homeostasis and
has also been postulated to play a role in tumorigenesis. We provide evidence that proper …
has also been postulated to play a role in tumorigenesis. We provide evidence that proper …
Lack of commensal flora in Helicobacter pylori–infected INS-GAS mice reduces gastritis and delays intraepithelial neoplasia
JL Lofgren, MT Whary, Z Ge, S Muthupalani, NS Taylor… - Gastroenterology, 2011 - Elsevier
BACKGROUND & AIMS: Transgenic FVB/N insulin-gastrin (INS-GAS) mice have high
circulating gastrin levels, and develop spontaneous atrophic gastritis and gastrointestinal …
circulating gastrin levels, and develop spontaneous atrophic gastritis and gastrointestinal …
Gastric colonisation with a restricted commensal microbiota replicates the promotion of neoplastic lesions by diverse intestinal microbiota in the Helicobacter pylori …
K Lertpiriyapong, MT Whary, S Muthupalani, JL Lofgren… - Gut, 2014 - gut.bmj.com
Objectives Gastric colonisation with intestinal flora (IF) has been shown to promote Helicobacter
pylori (Hp)-associated gastric cancer. However, it is unknown if the mechanism involves …
pylori (Hp)-associated gastric cancer. However, it is unknown if the mechanism involves …
Infection-induced colitis in mice causes dynamic and tissue-specific changes in stress response and DNA damage leading to colon cancer
…, NM Parry, S Muthupalani… - Proceedings of the …, 2012 - National Acad Sciences
Helicobacter hepaticus-infected Rag2 -/- mice emulate many aspects of human inflammatory
bowel disease, including the development of colitis and colon cancer. To elucidate …
bowel disease, including the development of colitis and colon cancer. To elucidate …
[HTML][HTML] Inflammation-Induced Cell Proliferation Potentiates DNA Damage-Induced Mutations In Vivo
O Kiraly, G Gong, W Olipitz, S Muthupalani… - PLoS …, 2015 - journals.plos.org
Mutations are a critical driver of cancer initiation. While extensive studies have focused on
exposure-induced mutations, few studies have explored the importance of tissue physiology …
exposure-induced mutations, few studies have explored the importance of tissue physiology …
Mice that express human interleukin-8 have increased mobilization of immature myeloid cells, which exacerbates inflammation and accelerates colon carcinogenesis
…, H Ariyama, ZA Dubeykovskaya, S Muthupalani… - Gastroenterology, 2013 - Elsevier
BACKGROUND & AIMS: Interleukin (IL)-8 has an important role in initiating inflammation in
humans, attracting immune cells such as neutrophils through their receptors CXCR1 and …
humans, attracting immune cells such as neutrophils through their receptors CXCR1 and …
High-fat diet accelerates carcinogenesis in a mouse model of Barrett's esophagus via interleukin 8 and alterations to the gut microbiome
…, AJ Dannenberg, M Pollak, PR Holt, S Muthupalani… - Gastroenterology, 2019 - Elsevier
Background & Aims Barrett’s esophagus (BE) is a precursor to esophageal adenocarcinoma
(EAC). Progression from BE to cancer is associated with obesity, possibly due to increased …
(EAC). Progression from BE to cancer is associated with obesity, possibly due to increased …
CCK2R identifies and regulates gastric antral stem cell states and carcinogenesis
Objective Progastrin is the incompletely cleaved precursor of gastrin that is secreted by G-cells
in the gastric antrum. Both gastrin and progastrin bind to the CCK2 receptor (Cckbr or …
in the gastric antrum. Both gastrin and progastrin bind to the CCK2 receptor (Cckbr or …
[HTML][HTML] Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer
CD11b + Gr-1 + myeloid-derived suppressor cells (MDSCs) expand in the spleen during
cancer and promote progression through suppression of cytotoxic T cells. An anti-inflammatory …
cancer and promote progression through suppression of cytotoxic T cells. An anti-inflammatory …