The human and mouse genomes contain instructions that specify RNAs and proteins and
govern the timing, magnitude, and cellular context of their production. To better delineate these …

Transcription factors are DNA-binding proteins that have key roles in gene regulation 1 , 2 .
Genome-wide occupancy maps of transcriptional regulators are important for understanding …

Background Interpreting genetic variants is one of the greatest challenges impeding analysis
of rapidly increasing volumes of genomic data from patients. For example, SHROOM3 is an …

Genetic regulation of gene expression, revealed by expression quantitative trait loci (eQTLs),
exhibits complex patterns of tissue-specific effects. Characterization of these patterns may …

Understanding how genetic variants impact molecular phenotypes is a key goal of functional
genomics, currently hindered by reliance on a single haploid reference genome. Here, we …

The small GTPase family is well-studied in cancer and cellular physiology. With 162 annotated
human genes, the family has a broad expression throughout cells of the body. Members …

… Charles B. Epstein … Surya B. Chhetri …

Background The commonly used laboratory rat, Rattus norvegicus, is unique in having multiple
Sry gene copies found on the Y chromosome, with different copies encoding amino acid …

Genetic variation influencing gene expression and splicing is a key source of phenotypic
diversity. Though invaluable, studies investigating these links in humans have been strongly …

The ethnopharmacological survey was undertaken to collect information about the use of
seven most used medicinal plants, viz. Gentiana depressa D. Don, Rhododendron setosum D. …