The American Thoracic Society, Centers for Disease Control and Prevention, and Infectious
Diseases Society of America jointly sponsored the development of this guideline for the …

Background Rifapentine-based regimens have potent antimycobacterial activity that may allow
for a shorter course in patients with drug-susceptible pulmonary tuberculosis. Methods In …

Background The Xpert MTB/RIF assay is an automated molecular test that has improved the
detection of tuberculosis and rifampicin resistance, but its sensitivity is inadequate in …

The immunogenetic basis of severe infections caused by bacille Calmette-Guérin vaccine
and environmental mycobacteria in humans remains largely unknown. We describe 18 …

IFN-gamma is critical in the immune response to mycobacterial infections, and deficits in IFN-gamma
production and response have been associated with disseminated nontuberculous …

Background Interferon γ receptor 1 (IFNγ R1) deficiency is a primary immunodeficiency with
allelic dominant and recessive mutations characterised clinically by severe infections with …

Diabetes mellitus (DM) is an emerging chronic health condition of developed and developing
countries. We conducted a retrospective cohort study of patients with active, culture-…

A genetic component to human mycobacterial disease susceptibility has long been postulated.
Over the past five years, mutations in the interferon-γ (IFNγ) receptor, IL-12 receptor β1 (IL…

… Correspondence and requests for reprints should be addressed to Susan E. Dorman, MD,
Johns Hopkins University Center for Tuberculosis Research, 1550 Orleans Street, Room 1M-…

Multidrug-resistant tuberculosis (MDR-TB), caused by drug-resistant strains of Mycobacterium
tuberculosis, is an increasingly serious problem worldwide. Here we examined a data set …