Tau aggregation occurs in neurodegenerative diseases including Alzheimer's disease and
many other disorders collectively termed tauopathies. trans-cellular propagation of tau …

Tau, a microtubule-associated protein, is implicated in the pathogenesis of Alzheimer9s
Disease (AD) in regard to both neurofibrillary tangle formation and neuronal network …

Objective We previously found a strong reduction in tau pathology and insoluble tau in P301S
tau transgenic mice following intracerebroventricular infusion of the anti‐tau antibody HJ8.…

A common remark among laypeople, and notably also among mental health workers, is that
individuals with mental illnesses use drugs as self-medication to allay clinical symptoms and …

Male sex is a strong risk factor for autism spectrum disorder (ASD). The leading theory for a "female
protective effect" (FPE) envisions males and females have "differing thresholds" …

The immense molecular diversity of neurons challenges our ability to understand the
genetic and cellular etiology of neuropsychiatric disorders. Leveraging knowledge from …

Within eukaryotic cells, translation is regulated independent of transcription, enabling
nuanced, localized, and rapid responses to stimuli. Neurons respond transcriptionally and …

Hypocretin (orexin; Hcrt)-containing neurons of the hypothalamus are essential for the
normal regulation of sleep and wake behaviors and have been implicated in feeding, anxiety, …

Human genetics have defined a new neurodevelopmental syndrome caused by loss-of-function
mutations in MYT1L, a transcription factor known for enabling fibroblast-to-neuron …

CCCTC-binding factor (CTCF) is an 11 zinc finger DNA-binding domain protein that regulates
gene expression by modifying 3D chromatin structure. Human mutations in CTCF cause …