We recently derived mouse expanded potential stem cells (EPSCs) from individual blastomeres
by inhibiting the critical molecular pathways that predispose their differentiation. EPSCs …

In initial work, we developed a 14-day culture protocol under potential GMP, chemically
defined conditions to generate chondroprogenitors from human embryonic stem cells (hESCs). …

We report a chemically defined, efficient, scalable and reproducible protocol for differentiation
of human embryonic stem cells (hESCs) toward chondrocytes. HESCs are directed …

This review covers the sequence of cell adhesion events occurring during implantation of
the mammalian embryo, concentrating on data from mouse and human. The analogy is …

Implantation of the embryo in the uterus is a critical and complex event and its failure is widely
considered an impediment to improved success in assisted reproduction. Depending on …

Leukaemia inhibitory factor (LIF) is one of the most important cytokines in the reproductive
tract. Without expression of LIF in the uterus, implantation of a blastocyst cannot begin. Yet, 13 …

Background In preimplantation mammalian development the transcription factor Sox2 (SRY-related
HMG-box gene 2) forms a complex with Oct4 and functions in maintenance of self-…

Human pluripotent stem cells (hPSCs) hold great promise for understanding kidney development
and disease. We reproducibly differentiated three genetically distinct wild-type hPSC …

Stem cell-derived somatic cells represent an unlimited resource for basic and translational
science. Although promising, there are significant hurdles that must be overcome. Our focus is …

The lack of in vitro tissue and organ models capable of mimicking human physiology severely
hinders the development and clinical translation of therapies and drugs with higher in vivo …