Background The study of autoinflammatory diseases has uncovered mechanisms underlying
cytokine dysregulation and inflammation. Methods We analyzed the DNA of an index …

Human immunodeficiency virus (HIV) disease leads to impaired B cell and antibody responses
through mechanisms that remain poorly defined. A unique memory B cell subpopulation (…

Background We observed a syndrome of intermittent fevers, early-onset lacunar strokes and
other neurovascular manifestations, livedoid rash, hepatosplenomegaly, and systemic …

In recent years, intense research efforts have been dedicated to elucidating the pathogenic
mechanisms of HIV-associated disease progression. In addition to the progressive depletion …

Human immunodeficiency virus (HIV) infection is generally characterized by inefficient viral
transmission; an acute phase of intense viral replication and dissemination to lymphoid …

Human immunodeficiency virus (HIV) persists in peripheral blood mononuclear cells despite
sustained, undetectable plasma viremia resulting from long-term antiretroviral therapy. …

Epidemiological observations in malaria endemic areas have long suggested a deficiency
in the generation and maintenance of B cell memory to Plasmodium falciparum (Pf) in …

A high prevalence and incidence of work-related musculoskeletal disorders have been reported
in construction work. Unlike industrial production-line activity, construction work, as well …

Background The discovery of potent and broadly neutralizing antibodies (bNAbs) against
human immunodeficiency virus (HIV) has made passive immunization a potential strategy for …

Background Mendelian analysis of disorders of immune regulation can provide insight into
molecular pathways associated with host defense and immune tolerance. Methods We …