Cell-mediated (type-1) immunity is necessary for immune protection against most intracellular
pathogens and, when excessive, can mediate organ-specific autoimmune destruction. …

Multiple sclerosis is a demyelinating disease, characterized by inflammation in the brain
and spinal cord, possibly due to autoimmunity. Large-scale sequencing of cDNA libraries, …

Stem cells reside in a specialized niche that regulates their abundance and fate. Components
of the niche have generally been defined in terms of cells and signaling pathways. We …

We have used homologous recombination in embryonic stem cells to generate mice with a
targeted disruption of the osteopontin (Opn, or Spp1, for secreted phosphoprotein 1) gene. …

Osteopontin (OPN) is a glycosylated phosphoprotein found in all body fluids and in the
proteinaceous matrix of mineralized tissues. It can function both as a cell attachment protein and …

Osteopontin is one of the major noncollagenous bone matrix proteins produced by
osteoblasts and osteoclasts, bone cells that are uniquely responsible for the remodeling of …

Osteopontin (OPN) was expressed in murine wild-type osteoclasts, localized to the basolateral,
clear zone, and ruffled border membranes, and deposited in the resorption pits during …

Reduced mechanical stress to bone in bedridden patients and astronauts leads to bone loss
and increase in fracture risk which is one of the major medical and health issues in modern …

Rheumatoid arthritis is one of the most critical diseases that impair the quality of life of
patients, but its pathogenesis has not yet been fully understood. Osteopontin (OPN) is an …

To clarify the role of OPN in bone formation under mechanical stress, we examined the
expression and the function of OPN in bone using an expansion force‐induced osteogenesis …