User profiles for Susana Direito

Susana Direito

University of Edinburgh
Verified email at ed.ac.uk
Cited by 922

Habitability: a review

CS Cockell, T Bush, C Bryce, S Direito, M Fox-Powell… - Astrobiology, 2016 - liebertpub.com
Habitability is a widely used word in the geoscience, planetary science, and astrobiology
literature, but what does it mean? In this review on habitability, we define it as the ability of an …

The significance of microbe-mineral-biomarker interactions in the detection of life on Mars and beyond

…, CHL Patty, IL Ten Kate, P Ehrenfreund, SOL Direito - Astrobiology, 2015 - liebertpub.com
The detection of biomarkers plays a central role in our effort to establish whether there is, or
was, life beyond Earth. In this review, we address the importance of considering mineralogy …

Sensitive life detection strategies for low-biomass environments: optimizing extraction of nucleic acids adsorbing to terrestrial and Mars analogue minerals

SOL Direito, A Marees… - FEMS microbiology …, 2012 - academic.oup.com
The adsorption of nucleic acids to mineral matrixes can result in low extraction yields and
negatively influences molecular microbial ecology studies, in particular for low-biomass …

[HTML][HTML] Soft matter science and the COVID-19 pandemic

WCK Poon, AT Brown, SOL Direito, DJM Hodgson… - Soft matter, 2020 - pubs.rsc.org
Much of the science underpinning the global response to the COVID-19 pandemic lies in
the soft matter domain. Coronaviruses are composite particles with a core of nucleic acids …

Predictable properties of fitness landscapes induced by adaptational tradeoffs

SG Das, SOL Direito, B Waclaw, RJ Allen, J Krug - Elife, 2020 - elifesciences.org
Fitness effects of mutations depend on environmental parameters. For example, mutations
that increase fitness of bacteria at high antibiotic concentration often decrease fitness in the …

A roadblock-and-kill mechanism of action model for the DNA-targeting antibiotic ciprofloxacin

N Ojkic, E Lilja, S Direito, A Dawson… - Antimicrobial agents …, 2020 - Am Soc Microbiol
Fluoroquinolones, antibiotics that cause DNA damage by inhibiting DNA topoisomerases,
are clinically important, but their mechanism of action is not yet fully understood. In particular, …

A wide variety of putative extremophiles and large beta-diversity at the Mars Desert Research Station (Utah)

SOL Direito, P Ehrenfreund, A Marees… - International Journal of …, 2011 - cambridge.org
Humankind's innate curiosity makes us wonder whether life is or was present on other
planetary bodies such as Mars. The EuroGeoMars 2009 campaign was organized at the Mars …

Systematic evaluation of bias in microbial community profiles induced by whole genome amplification

SOL Direito, E Zaura, M Little… - Environmental …, 2014 - Wiley Online Library
Whole genome amplification methods facilitate the detection and characterization of microbial
communities in low biomass environments. We examined the extent to which the actual …

Planetary science and exploration in the deep subsurface: results from the MINAR Program, Boulby Mine, UK

…, DC Cullen, MT Downs, SOL Direito… - International Journal of …, 2017 - cambridge.org
The subsurface exploration of other planetary bodies can be used to unravel their geological
history and assess their habitability. On Mars in particular, present-day habitable conditions …

Computational design of probes to detect bacterial genomes by multivalent binding

…, JD Farrell, Z Xing, D Joshi, S Direito… - Proceedings of the …, 2020 - National Acad Sciences
Rapid methods for diagnosis of bacterial infections are urgently needed to reduce inappropriate
use of antibiotics, which contributes to antimicrobial resistance. In many rapid diagnostic …