Objective Lacunar stroke is common (25% of ischemic strokes) and mostly because of an
intrinsic cerebral microvascular disease of unknown cause. Although considered primarily to …

White matter hyperintensities (WMH) of presumed vascular origin, also referred to as leukoaraiosis,
are a very common finding on brain magnetic resonance imaging (MRI) or computed …

Identifying genetic variants influencing human brain structures may reveal new biological
mechanisms underlying cognition and neuropsychiatric illness. The volume of the …

The hippocampal formation is a brain structure integrally involved in episodic memory, spatial
navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal …

White matter hyperintensities (WMH) of presumed vascular origin are a common finding in
brain magnetic resonance imaging of older individuals and contribute to cognitive and …

Objectives: Strong qualitative and quantitative evidence exists of white matter abnormalities
in both schizophrenia and bipolar disorder (BD). Diffusion tensor imaging (DTI) studies …

Objectives: Increased participation in leisure and physical activities may be cognitively protective.
Whether activity might protect the integrity of the brain's white matter, or reduce atrophy …

BACKGROUND: Abnormalities of white matter integrity have been repeatedly demonstrated
in both schizophrenia and bipolar disorder with voxel based methods. Because these …

Introduction Advanced machine learning methods might help to identify dementia risk from
neuroimaging, but their accuracy to date is unclear. Methods We systematically reviewed the …

Intracranial volume reflects the maximally attained brain size during development, and remains
stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain …