Excess caloric intake can lead to insulin resistance. The underlying reasons are complex
but likely related to ectopic lipid deposition in nonadipose tissue. We hypothesized that the …

More than one-third of the worldwide population is overweight or obese and therefore at risk
of developing type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more …

Disruptions of the melanocortin signaling system have been linked to obesity. We investigated
a possible role of the central nervous melanocortin system (CNS-Mcr) in the control of …

Background— Multiple pathways contribute to accelerated coronary atherosclerosis in
diabetics, including increased oxidative stress and inflammatory burden. Accordingly, the …

Advanced glycation end products (AGEs), known promoters of diabetic complications, form
abundantly in heated foods and are ingested in bioreactive forms. To test whether dietary …

Glucagon, an essential regulator of glucose homeostasis, also modulates lipid metabolism
and promotes weight loss, as reflected by the wasting observed in glucagonoma patients. …

Non‐alcoholic fatty liver disease ( NAFLD ) affects 25% of the population and can progress
to cirrhosis with limited treatment options. As the liver secretes most of the blood plasma …

Glucagon and thyroid hormone (T 3 ) exhibit therapeutic potential for metabolic disease but
also exhibit undesired effects. We achieved synergistic effects of these two hormones and …

Diet-induced obesity and its serious consequences such as diabetes, cardiovascular disease,
and cancer are rapidly becoming a major global health threat. Therefore, understanding …

Women and men, female and male animals and cells are biologically different, and
acknowledgement of this fact is critical to advancing medicine. However, incorporating concepts of …