Moloney murine leukemia virus causes thymic leukemias when injected into newborn mice.
A major determinant of the thymic disease specificity of Moloney virus genetically maps to …

We have previously identified a 160-kDa protein in human embryonic kidney (HEK) 293 cells
that undergoes rapid tyrosine phosphorylation in response to insulin (PY160) (Kuhné, MR, …

The insulin-regulated glucose transporter isotype GluT4 expressed only in muscle and adipose
cells is sequestered in a specific secretory vesicle. These vesicles harbor another major …

The insulin receptor substrates (IRSs) function in insulin signaling. Four members of the
family, IRS-1 through IRS-4, are known. Previously, mice with targeted disruption of the genes …

Major histocompatibility complex (MHC) class I molecules present peptides, produced
through cytosolic proteasomal degradation of cellular proteins, to cytotoxic T lymphocytes. In …

OBJECTIVE Rictor is an essential component of mammalian target of rapamycin (mTOR)
complex (mTORC) 2, a kinase that phosphorylates and activates Akt, an insulin signaling …

Rictor is an essential component of mTOR (mammalian target of rapamycin) complex 2 (mTORC2),
a kinase complex that phosphorylates Akt at Ser473 upon activation of …

The mammalian circadian system consists of a central oscillator in the suprachiasmatic nucleus
of the hypothalamus, which coordinates peripheral clocks in organs throughout the body…

Polycystic ovary syndrome (PCOS) is a common fertility disorder with metabolic sequelae.
Our lab previously characterized reproductive phenotypes in a prenatally androgenized (PNA) …

Insulin increases glucose transport by stimulating the trafficking of intracellular GLUT4 to the
cell surface, a process known as GLUT4 translocation. A key protein in signaling this …