Although several lung cancer susceptibility loci have been identified, much of the heritability
for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European …

Screening for distress in cancer patients is recommended by the National Comprehensive
Cancer Network, and a Distress Thermometer has previously been developed and empirically …

Background Patients with non-small-cell lung cancer (NSCLC) that is resistant to PD-1 and
PD-L1 (PD[L]-1)-targeted therapy have poor outcomes. Studies suggest that radiotherapy …

Mitochondrial complex I is the largest integral membrane enzyme of the respiratory chain
and consists of 44 different subunits encoded in the mitochondrial and nuclear genome. Its …

A new mechanism on regulation of mitochondrial energy metabolism is proposed on the
basis of reversible control of respiration by the intramitochondrial ATP/ADP ratio and slip of …

Apoptotic cell death can occur by two different pathways. Type 1 is initiated by the activation
of death receptors (Fas, TNF-receptor-family) on the plasma membrane followed by …

Life of higher organisms is essentially dependent on the efficient synthesis of ATP by oxidative
phosphorylation in mitochondria. An important and as yet unsolved question of energy …

The activity of cytochrome‐c oxidase, the terminal enzyme of the mitochondria) respiratory
chain, is known to be regulated by the substrate pressure, ie the ferro‐/ferricytochrome c ratio, …

Ancient DNA analysis has revealed an involvement of the bacterial pathogen Yersinia pestis
in several historical pandemics, including the second plague pandemic (Europe, mid-14 th …

To identify new susceptibility loci to lung cancer among diverse populations, we performed
cross-ancestry genome-wide association studies in European, East Asian and African …