Bendamustine in combination with rituximab for previously untreated patients with chronic lymphocytic leukemia: a multicenter phase II trial of the German Chronic …

…, KH Pflüger, S Schott, V Goede, S Isfort… - Journal of Clinical …, 2012 - ascopubs.org
Purpose We investigated the safety and efficacy of bendamustine and rituximab (BR) in
previously untreated patients with chronic lymphocytic leukemia (CLL). Patients and Methods In …

[HTML][HTML] Bleeding, thrombosis, and anticoagulation in myeloproliferative neoplasms (MPN): analysis from the German SAL-MPN-registry

…, S Parmentier, F Lang, R Hansen, S Isfort… - Journal of hematology & …, 2016 - Springer
Background Patients with Ph-negative myeloproliferative neoplasms (MPN), such as
polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF), are at …

[HTML][HTML] Calreticulin-mutant proteins induce megakaryocytic signaling to transform hematopoietic cells and undergo accelerated degradation and Golgi-mediated …

…, C Schubert, J Köhler, M Schemionek, S Isfort… - Journal of hematology & …, 2016 - Springer
Background Somatic calreticulin (CALR), Janus kinase 2 (JAK2), and thrombopoietin receptor
(MPL) mutations essentially show mutual exclusion in myeloproliferative neoplasms (MPN…

Improve hip fracture outcome in the elderly patient (iHOPE): a study protocol for a pragmatic, multicentre randomised controlled trial to test the efficacy of spinal versus …

…, F Hildebrand, RD Hilgers, A Hoeft, S Isfort… - BMJ open, 2018 - bmjopen.bmj.com
Introduction Hip fracture surgery is associated with high in-hospital and 30-day mortality
rates and serious adverse patient outcomes. Evidence from randomised controlled trials …

Second cancers in MPN: Survival analysis from an international study

…, A Tieghi, V Recasens, S Isfort… - American journal of …, 2020 - Wiley Online Library
One out of ten patients with Philadelphia‐negative myeloproliferative neoplasms (MPN) develop
a second cancer (SC): in such patients we aimed at assessing the survival impact of SC …

Comparison of flow‐FISH and MM–qPCR telomere length assessment techniques for the screening of telomeropathies

…, I Halfmeyer, N Estrada, B Xicoy, S Isfort… - Annals of the New …, 2020 - Wiley Online Library
Assessment of telomere length (TL) in peripheral blood leukocytes is part of the diagnostic
algorithm applied to patients with acquired bone marrow failure syndromes (BMFSs) and …

[HTML][HTML] Kidney dysfunction is associated with thrombosis and disease severity in myeloproliferative neoplasms: implications from the German Study Group for MPN …

…, M Bommer, HL Pahl, F Lang, M Kirschner, S Isfort… - Cancers, 2021 - mdpi.com
Simple Summary In patients with myeloproliferative neoplasms (MPN) and in patients with
kidney dysfunction, a higher rate of thrombosis has been reported compared with the general …

[HTML][HTML] Comparable effects of the androgen derivatives danazol, oxymetholone and nandrolone on telomerase activity in human primary hematopoietic cells from …

…, M Tometten, A Abels, B Rolles, S Isfort… - International Journal of …, 2020 - mdpi.com
Dyskeratosis congenita (DKC) is a rare inherited disease of impaired telomere maintenance
that progressively leads to multi-organ failure, including the bone marrow. By enhancing …

[HTML][HTML] Outcome of advanced chronic lymphocytic leukemia following different first-line and relapse therapies: a meta-analysis of five prospective trials by the German …

P Cramer, S Isfort, J Bahlo, S Stilgenbauer… - …, 2015 - ncbi.nlm.nih.gov
To evaluate the effect of first-line and subsequent therapies, the outcome of 1,558 patients
with chronic lymphocytic leukemia from five prospective phase II/III trials conducted between …

Androgen derivatives improve blood counts and elongate telomere length in adult cryptic dyskeratosis congenita

…, S Balabanov, B Rolles, S Isfort… - British journal of …, 2021 - Wiley Online Library
Dyskeratosis Congenita (DKC) is a systemic disorder caused by mutations resulting in impaired
telomere maintenance. Clinical features include bone marrow failure and an increased …