The aim of this study was to identify microRNAs in urinary exosomes that are differently
expressed in prostate cancer patients and healthy donors. For this purpose, RNA was extracted …

Background Sarcomas are rare, phenotypically heterogeneous cancers that disproportionately
affect the young. Outside rare syndromes, the nature, extent, and clinical significance of …

Background Recent developments in deep (next-generation) sequencing technologies are
significantly impacting medical research. The global analysis of protein coding regions in …

Colorectal cancer (CRC) is one of the leading causes of cancer related deaths and the
search for prognostic biomarkers that might improve treatment decisions is warranted. …

Inhibitory signaling during natural killer (NK) cell education translates into increased
responsiveness to activation; however, the intracellular mechanism for functional tuning by …

Molecular analysis of circulating tumor DNA (ctDNA) has a large potential for clinical
application by capturing tumor-specific aberrations through noninvasive sampling. In …

Aim To evaluate the activity and safety of the PD-1 antibody pembrolizumab in adult patients
with advanced osteosarcoma. Material and methods The study was a single-arm, open-…

Differentiation of osteoblasts from mesenchymal stem cells (MSCs) is an integral part of bone
development and homeostasis, and may when improperly regulated cause disease such …

In contrast to many other sarcoma subtypes, the chaotic karyotypes of osteosarcoma have
precluded the identification of pathognomonic translocations. We here report hundreds of …

Planning for adaptation to climate change is often regarded to be a local imperative and
considered to be more effective if grounded on a solid evidence base and recognisant of …