Bromodomains (BRDs) are protein interaction modules that specifically recognize ε-N-lysine
acetylation motifs, a key event in the reading process of epigenetic marks. The 61 BRDs in …

Immune responses against pathogens require that microbial components promote the activation
of antigen‐presenting cells (APCs). Autoimmune diseases and graft rejections occur in …

Chemical probes are powerful reagents with increasing impacts on biomedical research.
However, probes of poor quality or that are used incorrectly generate misleading results. To …

HMG1 (high mobility group 1) is a ubiquitous and abundant chromatin component. However,
HMG1 can be secreted by activated macrophages and monocytes, and can act as a …

Previous analyses of the uteroglobin gene promoter revealed a GT1 box which is also found
in the SV4O enhancer. The GT1 element in the context of the uteroglobin promoter is active …

The High Mobility Group Box (HMGB) chromosomal proteins have been known and studied
for a long time, but we have only recently started to understand their biological functions. …

Protein tyrosine phosphatases (PTPs) play a critical role in regulating cellular functions by
selectively dephosphorylating their substrates. Here we present 22 human PTP crystal …

Bromodomains have emerged as attractive candidates for the development of inhibitors
targeting gene transcription. Inhibitors of the bromo and extraterminal (BET) family recently …

Protein kinases play a pivotal role in cell signaling, and dysregulation of many kinases has
been linked to disease development. A large number of kinase inhibitors are therefore …

Expression analysis of genes encoding components of the phosphotyrosine signaling
system by cDNA array hybridization revealed elevated levels of FGFR4 transcripts in several …