Spindle multipolarity is prevented by centrosomal clustering

NJ Quintyne, JE Reing, DR Hoffelder, SM Gollin… - Science, 2005 - science.org
Most tumor cells are characterized by increased genomic instability and chromosome
segregational defects, often associated with hyperamplification of the centrosome and the …

Tumor escape from immune recognition: lethal recurrent melanoma in a patient associated with downregulation of the peptide transporter protein TAP-1 and loss of …

MJ Maeurer, SM Gollin, D Martin… - The Journal of …, 1996 - Am Soc Clin Investig
In the last few years, mutiple protein target antigens for immunorecognition by T cells have
been identified on human melanoma. How melanoma lesions escape from functional antigen-…

TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progression

…, AM Egloff, X Chen, VW Lui, JR Grandis, SM Gollin - Cancer research, 2012 - AACR
Frequent gene amplification of the receptor-activated calcium-dependent chloride channel
TMEM16A (TAOS2 or ANO1) has been reported in several malignancies. However, its …

Resolution of anaphase bridges in cancer cells

DR Hoffelder, L Luo, NA Burke, SC Watkins, SM Gollin… - Chromosoma, 2004 - Springer
Chromosomal instability is a key step in the generation of the cancer cell karyotype. An
indicator of unstable chromosomes is the presence of chromatin bridges during anaphase. We …

Head and neck squamous cell carcinoma cell lines: established models and rationale for selection

CJ Lin, JR Grandis, TE Carey, SM Gollin… - Head & Neck …, 2007 - Wiley Online Library
Background. Head and neck squamous cell carcinoma (HNSCC) cell lines are important
preclinical models in the search for novel and targeted therapies to treat head and neck cancer. …

Chromosomal instability and cytoskeletal defects in oral cancer cells

…, AH Enyenihi, I Petersen, SM Gollin - Proceedings of the …, 2000 - National Acad Sciences
Oral squamous cell carcinomas are characterized by complex, often near-triploid karyotypes
with structural and numerical variations superimposed on the initial clonal chromosomal …

[HTML][HTML] Somatic mutation and gain of copy number of PIK3CA in human breast cancer

…, Z Guo, A Chatterjee, D Goldenberg, SM Gollin… - Breast cancer …, 2005 - Springer
Introduction Phosphatidylinositol 3-kinases (PI3Ks) are a group of lipid kinases that regulate
signaling pathways involved in cell proliferation, adhesion, survival, and motility. Even …

Decreased expression of miR‐125b and miR‐100 in oral cancer cells contributes to malignancy

…, DM O'Dee, E Feingold, SM Gollin - Genes …, 2009 - Wiley Online Library
Altered microRNA (miRNA) expression profiles have been observed in numerous malignancies,
including oral squamous cell carcinoma (OSCC). However, their role in disease is not …

Uncommon Mutation, but Common Amplifications, of the PIK3CA Gene in Thyroid Tumors

…, Z Guo, S Hu, X Huang, SM Gollin… - The Journal of …, 2005 - academic.oup.com
Context: As in many other human cancers, overactivation of the phosphotidylinositol 3-kinase
(PI3K)/Akt signaling pathway occurs frequently in thyroid cancer, but the mechanism is not …

High-resolution mapping of the 11q13 amplicon and identification of a gene, TAOS1, that is amplified and overexpressed in oral cancer cells

X Huang, SM Gollin, S Raja… - Proceedings of the …, 2002 - National Acad Sciences
Amplification of chromosomal band 11q13 is a common event in human cancer. It has been
reported in about 45% of head and neck carcinomas and in other cancers including …