PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis

S Seino, T Shibasaki - Physiological reviews, 2005 - journals.physiology.org
Stimulus-secretion coupling is an essential process in secretory cells in which regulated
exocytosis occurs, including neuronal, neuroendocrine, endocrine, and exocrine cells. While an …

cAMP-GEFII is a direct target of cAMP in regulated exocytosis

…, H Yano, Y Matsuura, T Iwanaga, Y Takai, S Seino - Nature cell …, 2000 - nature.com
Although cAMP is well known to regulate exocytosis in many secretory cells, its direct target
in the exocytotic machinery is not known. Here we show that cAMP-GEFII, a cAMP sensor, …

Reconstitution of IKATP: An Inward Rectifier Subunit Plus the Sulfonylurea Receptor

…, J Inazawa, G Gonzalez, L Aguilar-Bryan, S Seino… - Science, 1995 - science.org
A member of the inwardly rectifying potassium channel family was cloned here. The channel,
called BIR (Kir6.2), was expressed in large amounts in rat pancreatic islets and glucose-…

Molecular biology of mammalian glucose transporters

…, J Takeda, D Lin, H Fukumoto, S Seino - Diabetes …, 1990 - Am Diabetes Assoc
The oxidation of glucose represents a major source of metabolic energy for mammaliancells.
However, because the plasma membrane is impermeable to polar molecules such as …

ATP-sensitive K+ channels in the hypothalamus are essential for the maintenance of glucose homeostasis

…, F Ashcroft, Y Minokoshi, J Roeper, S Seino - Nature …, 2001 - nature.com
Glucose-responsive (GR) neurons in the hypothalamus are thought to be critical in glucose
homeostasis, but it is not known how they function in this context. Kir6. 2 is the pore-forming …

GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure

…, T Shibasaki, SE Quaggin, PH Backx, S Seino… - Nature medicine, 2013 - nature.com
Glucagon-like peptide-1 receptor (GLP-1R) agonists exert antihypertensive actions through
incompletely understood mechanisms. Here we demonstrate that cardiac Glp1r expression …

[HTML][HTML] A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels

…, JPC Iv, CZ Wang, L Aguilar-Bryan, J Bryan, S Seino - Neuron, 1996 - cell.com
We have cloned an isoform of the sulfonylurea receptor (SUR), designated SUR2. Coexpression
of SUR2 and the inward rectifier K + channel subunit Kir6.2 in COS1 cells reconstitutes …

Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney.

…, K Wang, HS Tager, GI Bell, S Seino - Proceedings of the …, 1992 - National Acad Sciences
Somatostatin is a tetradecapeptide that is widely distributed in the body. It acts on multiple
organs including brain, pituitary, gut, exocrine and endocrine pancreas, adrenals, thyroid, and …

[HTML][HTML] Physiological and pathophysiological roles of ATP-sensitive K+ channels

S Seino, T Miki - Progress in biophysics and molecular biology, 2003 - Elsevier
ATP-sensitive potassium (K ATP ) channels are present in many tissues, including pancreatic
islet cells, heart, skeletal muscle, vascular smooth muscle, and brain, in which they couple …

ATP-sensitive potassium channels: a model of heteromultimeric potassium channel/receptor assemblies

S Seino - Annual review of physiology, 1999 - annualreviews.org
▪ Abstract ATP-sensitive K + channels (K ATP channels) play important roles in many cellular
functions by coupling cell metabolism to electrical activity. By cloning members of the novel …