The molecular chaperone protein Hsp90 has been widely discussed as a candidate gene for
developmental buffering. We used the methods of geometric morphometrics to analyze its …

Genetic capacitors moderate expression of heritable variation and provide a novel mechanism
for rapid evolution. The prototypic genetic capacitor, Hsp90, interfaces stress responses, …

Partial reduction of Hsp90 increases expression of morphological novelty in qualitative traits
of Drosophila and Arabidopsis, but the extent to which the Hsp90 chaperone also controls …

The most abundant cytoplasmic chaperone of eukaryotic cells, Hsp90 is a hub in developmental
regulatory networks and the first example described of the phenomenon of molecular …

Hsp90 controls dramatic phenotypic transitions in a wide array of morphological features of
many organisms. The genetic-background dependence of specific abnormalities and their …

Experimental measurements require calibration to transform measured signals into physically
meaningful values. The conventional approach has two steps: the experimenter deduces …

In a 2009 article in Cell van Oudenaarden and colleagues employed elegant experiments
and control theory to model perfect adaptation of the yeast osmotic stress response – precise …

The biological consequences of mutation depend on the translation of genotype into
phenotype. The genotype-phenotype map is controlled by developmental and physiological …

Microbes limit risk by stochastic bet hedging–low frequency expression of less fit, slow growing
cells constitutively preadapted against many stresses including antibiotics. By contrast, …

Regulatory evolution has frequently been proposed as the primary mechanism driving
morphological evolution. This is because regulatory changes may be less likely to cause …