Background Xenograft samples used to test anti-cancer drug efficacies and toxicities in vivo
contain an unknown mix of mouse and human cells. Evaluation of drug activity can be …

We have previously shown that topotecan, a topoisomerase I poison, inhibits hypoxia-inducible
factor (HIF)-1α protein accumulation by a DNA damage-independent mechanism. Here, …

The “Warburg effect,” also termed aerobic glycolysis, describes the increased reliance of
cancer cells on glycolysis for ATP production, even in the presence of oxygen. Consequently, …

Inhibition of hypoxia inducible factor-1 (HIF-1) is an attractive therapeutic strategy to target
the tumor microenvironment. However, HIF-1 inhibitors may have limited activity as single …

Purpose To describe the preclinical basis for further development of 17-dimethyl
aminoethylamino-17-demethoxygeldanamycin hydrochloride (17-DMAG, NSC 707545). Methods In …

Despite the role of EMT in metastasis and drug resistance, no standardized assessment of
EMT phenotypic heterogeneity in human carcinomas exists; the EMT-IFA allows for clinical …

In vivo anti-HIV efficacy of (+)-calanolide A has been evaluated in a hollow fiber mouse model.
It was demonstrated that the compound was capable of suppressing virus replication in …

Background Development of cancer therapeutics partially depends upon selection of
appropriate animal models. Therefore, improvements to model selection are beneficial. Results …

Purpose: The use of genetically engineered mouse (GEM) models for preclinical testing of
anticancer therapies is hampered by variable tumor latency, incomplete penetrance, and …

Here we report that B16F10 murine melanoma cells mimic endothelial cell behavior and the
angiogenic process in vitro and in vivo. Cord formation in vitro by tumor cells is stimulated …