[HTML][HTML] Animal models for COVID-19
…, GA Hamilton, AL Hartman, S Herfst, SJF Kaptein… - Nature, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the aetiological agent of
coronavirus disease 2019 (COVID-19), an emerging respiratory infection caused by the …
coronavirus disease 2019 (COVID-19), an emerging respiratory infection caused by the …
[PDF][PDF] Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches
…, E Cox, G Ferrero, V Wittamer, A Willaert, SJF Kaptein… - Cell, 2022 - cell.com
The liver is the largest solid organ in the body, yet it remains incompletely characterized.
Here we present a spatial proteogenomic atlas of the healthy and obese human and murine …
Here we present a spatial proteogenomic atlas of the healthy and obese human and murine …
[HTML][HTML] STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters
R Boudewijns, HJ Thibaut, SJF Kaptein, R Li… - Nature …, 2020 - nature.com
Emergence of SARS-CoV-2 causing COVID-19 has resulted in hundreds of thousands of
deaths. In search for key targets of effective therapeutics, robust animal models mimicking …
deaths. In search for key targets of effective therapeutics, robust animal models mimicking …
Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug
…, T De Burghgraeve, S Kaptein… - Journal of …, 2012 - academic.oup.com
Objectives Infection with yellow fever virus (YFV), the prototypic mosquito-borne flavivirus,
causes severe febrile disease with haemorrhage, multi-organ failure and a high mortality. …
causes severe febrile disease with haemorrhage, multi-organ failure and a high mortality. …
[HTML][HTML] The Viral Polymerase Inhibitor 7-Deaza-2'-C-Methyladenosine Is a Potent Inhibitor of In Vitro Zika Virus Replication and Delays Disease Progression in a …
…, D Schols, E Verbeken, SJF Kaptein… - PLoS neglected …, 2016 - journals.plos.org
Zika virus (ZIKV) is an emerging flavivirus typically causing a dengue-like febrile illness, but
neurological complications, such as microcephaly in newborns, have potentially been linked …
neurological complications, such as microcephaly in newborns, have potentially been linked …
Favipiravir at high doses has potent antiviral activity in SARS-CoV-2− infected hamsters, whereas hydroxychloroquine lacks activity
SJF Kaptein, S Jacobs, L Langendries… - Proceedings of the …, 2020 - National Acad Sciences
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly spread around the
globe after its emergence in Wuhan in December 2019. With no specific therapeutic and …
globe after its emergence in Wuhan in December 2019. With no specific therapeutic and …
[HTML][HTML] A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate
…, B Malengier-Devlies, L Liesenborghs, SJF Kaptein… - Nature, 2021 - nature.com
The expanding pandemic of coronavirus disease 2019 (COVID-19) requires the development
of safe, efficacious and fast-acting vaccines. Several vaccine platforms are being …
of safe, efficacious and fast-acting vaccines. Several vaccine platforms are being …
[HTML][HTML] Blocking NS3–NS4B interaction inhibits dengue virus in non-human primates
O Goethals, SJF Kaptein, B Kesteleyn, JF Bonfanti… - Nature, 2023 - nature.com
Dengue is a major health threat and the number of symptomatic infections caused by the
four dengue serotypes is estimated to be 96 million 1 with annually around 10,000 deaths 2 . …
four dengue serotypes is estimated to be 96 million 1 with annually around 10,000 deaths 2 . …
[HTML][HTML] Comparing infectivity and virulence of emerging SARS-CoV-2 variants in Syrian hamsters
…, X Zhang, L Delang, P Maes, SJF Kaptein… - …, 2021 - thelancet.com
Background Within one year after its emergence, more than 108 million people acquired
SARS-CoV-2 and almost 2·4 million succumbed to COVID-19. New SARS-CoV-2 variants of …
SARS-CoV-2 and almost 2·4 million succumbed to COVID-19. New SARS-CoV-2 variants of …
A pan-serotype dengue virus inhibitor targeting the NS3–NS4B interaction
SJF Kaptein, O Goethals, D Kiemel, A Marchand… - Nature, 2021 - nature.com
Dengue virus causes approximately 96 million symptomatic infections annually, manifesting
as dengue fever or occasionally as severe dengue 1 , 2 . There are no antiviral agents …
as dengue fever or occasionally as severe dengue 1 , 2 . There are no antiviral agents …