830 PFEFFER & ROTHMAN specify the localization of each nascent protein must reside in
its sequence or structure. The transport machinery that recognizes these signals distributes …

Rab proteins represent a large family of ras‐like GTPases that regulate distinct vesicular
transport events at the level of membrane targeting and/or fusion. We report here the primary …

Ten years ago, 20 Rab proteins had been identified as organelle-specific GTPases, and two
were known to be essential for vesicle targeting in yeast. Today, more than 60 mammalian …

Protein secretion and the transport of proteins between membrane-bound compartments
are mediated by small, membrane-bound vesicles. Here I review what is known about the …

Mannose 6-phosphate receptors (MPRs) transport newly synthesized lysosomal hydrolases
from the Golgi to prelysosomes and then return to the Golgi for another round of transport. …

10.7554/eLife.31012.001 We previously reported that Parkinson’s disease (PD) kinase
LRRK2 phosphorylates a subset of Rab GTPases on a conserved residue in their switch-II …

Ebola and Marburg filoviruses cause deadly outbreaks of haemorrhagic fever. Despite
considerable efforts, no essential cellular receptors for filovirus entry have been identified. We …

Newly synthesized lysosomal enzymes bind to mannose 6-phosphate receptors (MPRs) in
the TGN, and are carried to prelysosomes, where they are released. MPRs then return to the …

Mannose 6-phosphate receptors (MPRs) are transported from endosomes to the trans-Golgi
via a transport process that requires the Rab9 GTPase and the cargo adaptor TIP47. We …

Highlights • Rab GTPases recruit distinct sets of effector proteins to membrane microdomains.
• Rab-bound effectors confer unique functionalities to membrane microdomains. • Activity-…