The bacterial cell envelope

TJ Silhavy, D Kahne, S Walker - Cold Spring Harbor …, 2010 - cshperspectives.cshlp.org
The bacteria cell envelope is a complex multilayered structure that serves to protect these
organisms from their unpredictable and often hostile environment. The cell envelopes of most …

Wall teichoic acids of gram-positive bacteria

…, JP Santa Maria Jr, S Walker - Annual review of …, 2013 - annualreviews.org
The peptidoglycan layers of many gram-positive bacteria are densely functionalized with
anionic glycopolymers known as wall teichoic acids (WTAs). These polymers play crucial roles …

SEDS proteins are a widespread family of bacterial cell wall polymerases

…, T Uehara, JJ Mekalanos, D Kahne, S Walker… - Nature, 2016 - nature.com
Elongation of rod-shaped bacteria is mediated by a dynamic peptidoglycan-synthetizing
machinery called the Rod complex. Here we report that, in Bacillus subtilis, this complex is …

Structure of human O-GlcNAc transferase and its complex with a peptide substrate

MB Lazarus, Y Nam, J Jiang, P Sliz, S Walker - Nature, 2011 - nature.com
The essential mammalian enzyme O-linked β-N-acetylglucosamine transferase (O-GlcNAc
transferase, here OGT) couples metabolic status to the regulation of a wide variety of cellular …

Synthetic lethal compound combinations reveal a fundamental connection between wall teichoic acid and peptidoglycan biosyntheses in Staphylococcus aureus

…, E Mylonakis, BJ Wilkinson, S Walker - ACS chemical …, 2011 - ACS Publications
Methicillin resistance in Staphylococcus aureus depends on the production of mecA, which
encodes penicillin-binding protein 2A (PBP2A), an acquired peptidoglycan transpeptidase (…

Glycosylation of unreactive substrates

D Kahne, S Walker, Y Cheng… - Journal of the American …, 1989 - ACS Publications
Figure 2. HREELS of the c (2X2)-N surface exposed to 10" 7 Torr of H2 at 400 Kfor 50 min (wide
range spectrum) and growth of NH stretching vibration peakat 3190 cm" 1 in the …

FtsW is a peptidoglycan polymerase that is functional only in complex with its cognate penicillin-binding protein

…, AC Kruse, D Kahne, TG Bernhardt, S Walker - Nature …, 2019 - nature.com
The peptidoglycan cell wall is essential for the survival and morphogenesis of bacteria 1 .
For decades, it was thought that only class A penicillin-binding proteins (PBPs) and related …

Structural snapshots of the reaction coordinate for O-GlcNAc transferase

…, GE Whitworth, DJ Vocadlo, S Walker - Nature chemical …, 2012 - nature.com
Visualization of the reaction coordinate undertaken by glycosyltransferases has remained
elusive but is critical for understanding this important class of enzyme. Using substrates and …

[HTML][HTML] Wall teichoic acid function, biosynthesis, and inhibition

…, J Campbell, TC Meredith, S Walker - … : a European journal of …, 2010 - ncbi.nlm.nih.gov
One of the major differences between Gram-negative and Gram-positive organisms is the
presence or absence of an outer membrane (Figure 1). In Gram-negative organisms, the outer …

Standardized descriptions of primate locomotor and postural modes

KD Hunt, JGH Cant, DL Gebo, MD Rose, SE Walker… - Primates, 1996 - Springer
As quantitative studies on primate positional behavior accumulate the lack of a standard
positional mode terminology is becoming an increasingly serious deficiency. Inconsistent use of …