To facilitate scalable profiling of single cells, we developed split-pool ligation-based transcriptome
sequencing (SPLiT-seq), a single-cell RNA-seq (scRNA-seq) method that labels the …

As an essential innate immune population for maintaining body homeostasis and warding
off foreign pathogens, macrophages display high plasticity and perform diverse supportive …

Transferrin is a well-studied ligand for tumor targeting due to upregulation of transferrin
receptors in numerous cancer cell types. Here, we report the development of a transferrin-…

Linear and branched poly(ethylenimines), lPEI and bPEI, respectively, grafted with β-cyclodextrin
are prepared to give CD−lPEI and CD−bPEI, respectively, and are investigated as in …

The extracellular matrix of solid tumors presents a transport barrier that restricts nanoparticle
penetration, thereby limiting the efficacy of nanosized delivery vehicles for cancer imaging …

Despite the rising global incidence of central nervous system (CNS) disorders, CNS drug
development remains challenging, with high costs, long pathways to clinical use and high …

Most current cancer therapies focus on killing malignant cells, but these cells are often genetically
unstable and can become resistant to chemotherapy. Tumor-associated macrophages …

The development of targeted vehicles for systemic drug delivery relies on optimizing both the
cell‐targeting ligand and the physicochemical characteristics of the nanoparticle carrier. A …

Polyplex-mediated gene therapy is a promising alternative to viral gene therapy. One challenge
to these synthetic carriers is reduced transfection efficiencies in vivo compared to those …

The challenges of evolution in a complex biochemical environment, coupling genotype to
phenotype and protecting the genetic material, are solved elegantly in biological systems by …