[HTML][HTML] MicroRNA-148a is down-regulated in human pancreatic ductal adenocarcinomas and regulates cell survival by targeting CDC25B
ST Liffers, JB Munding, M Vogt, JD Kuhlmann… - Laboratory …, 2011 - Elsevier
MicroRNAs (miRNAs: short non-coding RNAs) are emerging as a class of potential novel
tumor markers, as their dysregulation is being increasingly reported in various types of cancers…
tumor markers, as their dysregulation is being increasingly reported in various types of cancers…
Global microRNA expression profiling of microdissected tissues identifies miR‐135b as a novel biomarker for pancreatic ductal adenocarcinoma
…, A Urbanik, H Zöllner, ST Liffers… - … journal of cancer, 2012 - Wiley Online Library
Pancreatic ductal adenocarcinoma (PDAC) is known for its poor prognosis resulting from
being diagnosed at an advanced stage. Accurate early diagnosis and new therapeutic …
being diagnosed at an advanced stage. Accurate early diagnosis and new therapeutic …
[PDF][PDF] Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis
…, K Ueffing, S Nothdurft, S Oeck, A Paul, ST Liffers… - Cell Reports, 2021 - cell.com
Statins are among the most commonly prescribed drugs, and around every fourth person
above the age of 40 is on statin medication. Therefore, it is of utmost clinical importance to …
above the age of 40 is on statin medication. Therefore, it is of utmost clinical importance to …
Lasting response by vertical inhibition with cetuximab and trametinib in KRAS‐mutated colorectal cancer patient‐derived xenografts
…, A Maghnouj, T Li, B Verdoodt, ST Liffers… - Molecular …, 2023 - Wiley Online Library
Although approximately half of all metastatic colorectal cancers (mCRCs) harbour mutations
in KRAS or NRAS, hardly any progress has been made regarding targeted treatment for this …
in KRAS or NRAS, hardly any progress has been made regarding targeted treatment for this …
[HTML][HTML] Secondary resistance to anti-EGFR therapy by transcriptional reprogramming in patient-derived colorectal cancer models
D Vangala, S Ladigan, ST Liffers, S Noseir… - Genome medicine, 2021 - Springer
Background The development of secondary resistance (SR) in metastatic colorectal cancer (mCRC)
treated with anti-epidermal growth factor receptor (anti-EGFR) antibodies is not fully …
treated with anti-epidermal growth factor receptor (anti-EGFR) antibodies is not fully …
[HTML][HTML] Keratin 23, a novel DPC4/Smad4 target gene which binds 14-3-3ε
ST Liffers, A Maghnouj, JB Munding, R Jackstadt… - BMC cancer, 2011 - Springer
Background Inactivating mutations of SMAD4 are frequent in metastatic colorectal carcinomas.
In previous analyses, we were able to show that restoration of Smad4 expression in …
In previous analyses, we were able to show that restoration of Smad4 expression in …
[HTML][HTML] Salinomycin increases chemosensitivity to the effects of doxorubicin in soft tissue sarcomas
ST Liffers, DJ Tilkorn, I Stricker, CG Junge, S Al-Benna… - BMC cancer, 2013 - Springer
Background Chemotherapy for soft tissue sarcomas remains unsatisfactory due to their low
chemosensitivity. Even the first line chemotherapeutic agent doxorubicin only yields a …
chemosensitivity. Even the first line chemotherapeutic agent doxorubicin only yields a …
[HTML][HTML] MEK Inhibition Targets Cancer Stem Cells and Impedes Migration of Pancreatic Cancer Cells In Vitro and In Vivo
…, A Hidalgo-Sastre, L Dierichs, ST Liffers… - Stem Cells …, 2019 - hindawi.com
Pancreatic ductal adenocarcinoma (PDAC) remains a devastating disease with a very poor
prognosis. At the same time, its incidence is on the rise, and PDAC is expected to become …
prognosis. At the same time, its incidence is on the rise, and PDAC is expected to become …
[HTML][HTML] Functional noninvasive detection of glycolytic pancreatic ductal adenocarcinoma
…, SS Lueong, AM Winkelkotte, ST Liffers… - Cancer & …, 2022 - Springer
Background Pancreatic ductal adenocarcinoma (PDAC) lacks effective treatment options
beyond chemotherapy. Although molecular subtypes such as classical and QM (quasi-…
beyond chemotherapy. Although molecular subtypes such as classical and QM (quasi-…
[HTML][HTML] Unintended spread of a biosafety level 2 recombinant retrovirus
…, HE Meyer, K Stühler, ST Liffers, K Überla, T Grunwald - Retrovirology, 2009 - Springer
Background Contamination of vertebrate cell lines with animal retroviruses has been documented
repeatedly before. Although such viral contaminants can be easily identified with high …
repeatedly before. Although such viral contaminants can be easily identified with high …