Methane biogenesis in methanogens is mediated by methyl-coenzyme M reductase, an
enzyme that is also responsible for the utilization of methane through anaerobic methane …

SARS-CoV-2 nonstructural protein 3 (Nsp3) contains a macrodomain that is essential for
coronavirus pathogenesis and is thus an attractive target for drug development. This …

Proteins interacting with ADP-ribosyl groups are often involved in disease-related pathways
or viral infections, making them attractive drug targets. We present a robust and accessible …

Tankyrases 1 and 2 are central biotargets in the WNT/β-catenin signaling and Hippo
signaling pathways. We have previously developed tankyrase inhibitors bearing a 1,2,4-triazole …

Tankyrases catalyse poly-ADP-ribosylation of their binding partners and the modification
serves as a signal for the subsequent proteasomal degradation of these proteins. Tankyrases …

Tankyrase 1 and 2 (TNKS1/2) catalyze post-translational modification by poly-ADP-ribosylation
of a plethora of target proteins. In this function, TNKS1/2 also impact the WNT/β-catenin …

… Author links open overlay panel Sven T. Sowa 1 2 , Antti Moilanen 1 , Ekaterina Biterova 1 ,
… involved in ER calcium homeostasis and in integrin-maturation in MZ B cells and T cells.6, 7 …

We report [1,2,4]triazolo[3,4-b]benzothiazole (TBT) as a new inhibitor scaffold, which
competes with nicotinamide in the binding pocket of human poly- and mono-ADP-ribosylating …

ADP‐ribosylation is a post‐translational modification catalyzed by writer enzymes – ADP‐ribosyltransferases.
The modification is part of many signaling events, can modulate the …

While human poly-ADP-ribose chain generating poly-ARTs, PARP1 and 2 and TNKS1 and 2,
have been widely characterized, less is known on the pathophysiological roles of the mono…