INTRODUCTION The emergence of three lethal coronaviruses in <20 years and the urgency
of the COVID-19 pandemic have prompted efforts to develop new therapeutic strategies, …

The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed hundreds …

The origin of SARS-CoV-2 variants of concern remains unclear. Here, we test whether intra-host
virus evolution during persistent infections could be a contributing factor by …

Cells rapidly respond to replication stress actively slowing fork progression and inducing fork
reversal. How replication fork plasticity is achieved in the context of nuclear organization is …

In spring 2021, an increasing number of infections was observed caused by the hitherto
rarely described SARS-CoV-2 variant A.27 in south-west Germany. From December 2020 to …

Histone lysine methylation is generally performed by SET domain methyltransferases and
regulates chromatin structure and gene expression. Here, we identify human C21orf127 (…

Recent years have provided considerable insights into the dynamic nature of the cell nucleus,
which is constantly reorganizing its genome, controlling its size and shape, as well as …

Nuclear actin participates in a continuously expanding list of core processes within eukaryotic
nuclei, including the maintenance of genomic integrity. In response to DNA damage, …

Our current understanding of biomolecular condensate formation is largely based on
observing the final near-equilibrium condensate state. Despite expectations from classical …

Complement factor C5a was originally identified as a powerful promoter of inflammation
through activation of the C5a receptor 1 (C5ar1). Recent evidence suggests involvement of C5a …