Background: Inflammation is a significant contributor to neuronal death and dysfunction
following traumatic brain injury (TBI). Recent evidence suggests that interferons may be a key …

Subcellular location and activation of Tank Binding Kinase 1 (TBK1) govern precise progression
through mitosis. Either loss of activated TBK1 or its sequestration from the centrosomes …

PINK1, a serine/threonine ubiquitin kinase, and Parkin, an E3 ubiquitin ligase, work in
coordination to target damaged mitochondria to the lysosome in a process called mitophagy. This …

While originally identified as an antiviral pathway, recent work has implicated that cyclic
GMP-AMP-synthase-Stimulator of Interferon Genes (cGAS-STING) signaling is playing a critical …

SARS-CoV-2 causes the severe respiratory disease COVID-19. Remdesivir (RDV) was the
first fast-tracked FDA approved treatment drug for COVID-19. RDV acts as an antiviral …

Background Inflammation is a key contributor of neuronal death and dysfunction following
traumatic brain injury (TBI). Recent evidence suggests that interferons may be a key regulator …

Regeneration of cardiomyocytes, endothelial cells and vascular smooth muscle cells (three
major lineages of cardiac tissues) following myocardial infarction is the critical step to …

Mitosis is a precisely regulated cellular mechanism that governs fundamental processes like
embryogenesis, development, and tissue regeneration. Prenatal mitotic errors can cause …

The role of many lncRNAs in cancer remains elusive including that for a Prostate Cancer
Associated Transcript 92 (PCAT92). PCAT92 shares the locus on chromosome 13 with ABCC4 …

Accurate prediction of monthly runoff is critical for effective water resource management and
flood forecasting in river basins. In this study, we developed a hybrid deep learning (DL) …