User profiles for Swamy R. Adapa
Swamy Rakesh AdapaResearch Scientist, Rays Jiang Lab, University of South Florida Verified email at mail.usf.edu Cited by 1666 |
Uncovering the essential genes of the human malaria parasite Plasmodium falciparum by saturation mutagenesis
INTRODUCTION Malaria remains a devastating global parasitic disease, with the majority
of malaria deaths caused by the highly virulent Plasmodium falciparum. The extreme AT-bias …
of malaria deaths caused by the highly virulent Plasmodium falciparum. The extreme AT-bias …
[PDF][PDF] Lysophosphatidylcholine regulates sexual stage differentiation in the human malaria parasite Plasmodium falciparum
Transmission represents a population bottleneck in the Plasmodium life cycle and a key
intervention target of ongoing efforts to eradicate malaria. Sexual differentiation is essential for …
intervention target of ongoing efforts to eradicate malaria. Sexual differentiation is essential for …
[HTML][HTML] Malaria infected red blood cells release small regulatory RNAs through extracellular vesicles
The parasite Plasmodium falciparum causes the most severe form of malaria. Cell
communication between parasites is an important mechanism to control population density and …
communication between parasites is an important mechanism to control population density and …
Characterization of the dual role of Plasmodium falciparum DNA methyltransferase in regulating transcription and translation
…, SR Adapa, EP Quinlivan, R Jiang… - Nucleic Acids …, 2023 - academic.oup.com
DNA modifications are critical in fine-tuning the biological processes in model organisms.
However, the presence of cytosine methylation (5mC) and the function of the putative DNA …
However, the presence of cytosine methylation (5mC) and the function of the putative DNA …
[HTML][HTML] The apicoplast link to fever-survival and artemisinin-resistance in the malaria parasite
The emergence and spread of Plasmodium falciparum parasites resistant to front-line
antimalarial artemisinin-combination therapies (ACT) threatens to erase the considerable gains …
antimalarial artemisinin-combination therapies (ACT) threatens to erase the considerable gains …
[HTML][HTML] A unique class of Zn2+-binding serine-based PBPs underlies cephalosporin resistance and sporogenesis in Clostridioides difficile
Abstract Treatment with β-lactam antibiotics, particularly cephalosporins, is a major risk
factor for Clostridioides difficile infection. These broad-spectrum antibiotics irreversibly inhibit …
factor for Clostridioides difficile infection. These broad-spectrum antibiotics irreversibly inhibit …
[HTML][HTML] Unraveling the Plasmodium vivax sporozoite transcriptional journey from mosquito vector to human host
Malaria parasites transmitted by mosquito bite are remarkably efficient in establishing human
infections. The infection process requires roughly 30 minutes and is highly complex as …
infections. The infection process requires roughly 30 minutes and is highly complex as …
[HTML][HTML] Altered expression of K13 disrupts DNA replication and repair in Plasmodium falciparum
J Gibbons, KA Button-Simons, SR Adapa, S Li… - BMC genomics, 2018 - Springer
Background Plasmodium falciparum exhibits resistance to the artemisinin component of the
frontline antimalarial treatment Artemisinin-based Combination Therapy in South East Asia. …
frontline antimalarial treatment Artemisinin-based Combination Therapy in South East Asia. …
Role of mono-and divalent surface cations on the structure and adsorption behavior of water on mica surface
Understanding solid–water(vapor) interfacial systems is relevant for both industrial and
academic scenarios for their presence in wide areas ranging from tribology to geochemistry. …
academic scenarios for their presence in wide areas ranging from tribology to geochemistry. …
[HTML][HTML] An adaptable soft-mold embossing process for fabricating optically-accessible, microfeature-based culture systems and application toward liver stage …
SP Maher, AJ Conway, A Roth, SR Adapa, P Cualing… - Lab on a Chip, 2020 - pubs.rsc.org
Advanced cell culture methods for modeling organ-level structure have been demonstrated
to replicate in vivo conditions more accurately than traditional in vitro cell culture. Given that …
to replicate in vivo conditions more accurately than traditional in vitro cell culture. Given that …