User profiles for Sweelin Chew

Sweelin Chew

Postdoctoral researcher, University of Eastern Finland
Verified email at uef.fi
Cited by 200

[HTML][HTML] Impairment of mitochondrial function by particulate matter: Implications for the brain

S Chew, N Kolosowska, L Saveleva, T Malm… - Neurochemistry …, 2020 - Elsevier
Research efforts in the past decades have provided insight into the adverse health effects of
air pollution exposure. Exposure to airborne particulate matter is known to impair the …

[HTML][HTML] Neuron-astrocyte transmitophagy is altered in Alzheimer's disease

…, G Goldsteins, J Koistinaho, T Malm, S Chew… - Neurobiology of …, 2022 - Elsevier
Under physiological conditions in vivo astrocytes internalize and degrade neuronal
mitochondria in a process called transmitophagy. Mitophagy is widely reported to be impaired in …

[HTML][HTML] Single-cell RNA-Seq analysis of olfactory mucosal cells of Alzheimer's disease patients

…, AM Koivisto, T Malm, AR White, R Giugno, S Chew… - Cells, 2022 - mdpi.com
Olfaction is orchestrated by olfactory mucosal cells located in the upper nasal cavity. Olfactory
dysfunction manifests early in several neurodegenerative disorders including Alzheimer’s …

[HTML][HTML] Human-derived air–liquid interface cultures decipher Alzheimer's disease–SARS-CoV-2 crosstalk in the olfactory mucosa

…, P Singh, J Topinka, O Vapalahti, S Chew… - Journal of …, 2023 - Springer
Background The neurological effects of the coronavirus disease of 2019 (COVID-19) raise
concerns about potential long-term consequences, such as an increased risk of Alzheimer's …

[HTML][HTML] Urban air particulate matter induces mitochondrial dysfunction in human olfactory mucosal cells

S Chew, R Lampinen, L Saveleva, P Korhonen… - Particle and Fibre …, 2020 - Springer
Background The adverse effects of air pollutants including particulate matter (PM) on the
central nervous system is increasingly reported by epidemiological, animal and post-mortem …

[HTML][HTML] Upregulation of Integrin beta-3 in astrocytes upon Alzheimer's disease progression in the 5xFAD mouse model

…, N Thind, C Andrès, R Lampinen, S Chew… - Neurobiology of …, 2024 - Elsevier
Integrins are receptors that have been linked to various brain disorders, including Alzheimer's
disease (AD), the most prevalent neurodegenerative disorder. While Integrin beta-3 (ITGB3…

[HTML][HTML] Emissions from modern engines induce distinct effects in human olfactory mucosa cells, depending on fuel and aftertreatment

…, J Topinka, R Giugno, P Aakko-Saksa, S Chew… - Science of the Total …, 2023 - Elsevier
Ultrafine particles (UFP) with a diameter of ≤0.1 μm, are contributors to ambient air
pollution and derived mainly from traffic emissions, yet their health effects remain poorly …

[HTML][HTML] Subacute inhalation of ultrafine particulate matter triggers inflammation without altering amyloid beta load in 5xFAD mice

L Saveleva, P Vartiainen, V Górová, S Chew, I Belaya… - Neurotoxicology, 2022 - Elsevier
Epidemiological studies reveal that air pollution exposure may exacerbate neurodegeneration.
Ultrafine particles (UFPs) are pollutants that remain unregulated in ambient air by …

[HTML][HTML] The interaction between circulating cell-free mitochondrial DNA and inflammatory cytokines in predicting human mental health issue risk in adolescents: an …

A Alatalo, I de Sousa Maciel, N Kucháriková, S Chew… - Biomedicines, 2023 - mdpi.com
Adolescence is often a challenging time in which psychiatric issues have a strong connection
to mental health disorders later in life. The early identification of the problems can reduce …

[HTML][HTML] TUBE project: Transport-derived ultrafines and the brain effects

…, FR Cassee, RO Carare, S Chew… - International Journal of …, 2021 - mdpi.com
The adverse effects of air pollutants on the respiratory and cardiovascular systems are
unquestionable. However, in recent years, indications of effects beyond these organ systems …