Nutrition exerts considerable effects on health, and dietary interventions are commonly
used to treat diseases of metabolic aetiology. Although cancer has a substantial metabolic …

Methionine uptake and metabolism is involved in a host of cellular functions including
methylation reactions, redox maintenance, polyamine synthesis and coupling to folate metabolism…

Mitochondrial metabolism is an attractive target for cancer therapy 1 , 2 . Reprogramming
metabolic pathways could improve the ability of metabolic inhibitors to suppress cancers with …

Cell proliferation can be dependent on the non-essential amino acid serine, and dietary
restriction of serine inhibits tumor growth, but the underlying mechanisms remain incompletely …

Methionine metabolism is critical for epigenetic maintenance, redox homeostasis, and animal
development. However, the regulation of methionine metabolism remains unclear. Here, …

Dystonia is a brain disorder causing involuntary, often painful movements. Apart from a role
for dopamine deficiency in some forms, the cellular mechanisms underlying most dystonias …

Studies have shown that tumors commonly exhibit normal or enhanced respiration in
addition to glycolytic metabolism. In this issue, Courtney et al. (2018) report a reduction in …

Background While self-reported exercise is associated with a reduction in the risk of
recurrence in colorectal cancer, the molecular mechanisms underpinning this relationship are …

Codeletions of gene loci containing tumor suppressors and neighboring metabolic enzymes
present an attractive synthetic dependency in cancers. However, the impact that these …

Cancer cells have different nutritional requirements from their normal counterparts, and rewire
their metabolism to support uncontrolled proliferation. In recent years, extensive study of …