User profiles for Sydney R. Coffey
 | Sydney R CoffeyPeaceHealth St Joseph Medical Center Verified email at peacehealth.org Cited by 155 |
Transcriptional regulatory networks underlying gene expression changes in Huntington's disease
Transcriptional changes occur presymptomatically and throughout Huntington's disease (
HD ), motivating the study of transcriptional regulatory networks ( TRN s) in HD . We …
HD ), motivating the study of transcriptional regulatory networks ( TRN s) in HD . We …
Single-nucleus RNA-seq reveals dysregulation of striatal cell identity due to huntington's disease mutations
Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder caused by
a trinucleotide expansion in exon 1 of the huntingtin (HTT) gene. Cell death in HD occurs …
a trinucleotide expansion in exon 1 of the huntingtin (HTT) gene. Cell death in HD occurs …
[HTML][HTML] Motivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegeneration in the B6.HttQ111/+ model of Huntington's …
We investigated the appearance and progression of disease-relevant signs in the B6.Htt
Q111/+ mouse, a genetically precise model of the mutation that causes Huntington’s disease (…
Q111/+ mouse, a genetically precise model of the mutation that causes Huntington’s disease (…
Huntingtin loss in hepatocytes is associated with altered metabolism, adhesion, and liver zonation
Huntington’s disease arises from a toxic gain of function in the huntingtin (HTT) gene. As a
result, many HTT-lowering therapies are being pursued in clinical studies, including those …
result, many HTT-lowering therapies are being pursued in clinical studies, including those …
[HTML][HTML] Peripheral huntingtin silencing does not ameliorate central signs of disease in the B6.HttQ111/+ mouse model of Huntington's disease
Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease whose
predominant neuropathological signature is the selective loss of medium spiny neurons in the …
predominant neuropathological signature is the selective loss of medium spiny neurons in the …
[HTML][HTML] Early detection of apathetic phenotypes in Huntington's disease knock-in mice using open source tools
Apathy is one of the most prevalent and progressive psychiatric symptoms in Huntington’s
disease (HD) patients. However, preclinical work in HD mouse models tends to focus on …
disease (HD) patients. However, preclinical work in HD mouse models tends to focus on …
Huntingtin lowering reduces somatic instability at CAG-expanded loci
Expanded trinucleotide repeats cause many human diseases, including Huntington’s
disease (HD). Recent studies indicate that somatic instability of these repeats contributes to …
disease (HD). Recent studies indicate that somatic instability of these repeats contributes to …
Altered Huntingtin-Chromatin Interactions Predict Transcriptional and Epigenetic Changes in Huntington's Disease
Progressive striatal gene expression changes and epigenetic alterations are a prominent
feature of Huntington’s disease (HD), but direct relationships between the huntingtin (HTT) …
feature of Huntington’s disease (HD), but direct relationships between the huntingtin (HTT) …
Genome-scale transcriptional regulatory network models for the mouse and human striatum predict roles for SMAD3 and other transcription factors in Huntington's …
Transcriptional changes occur presymptomatically and throughout Huntington’s Disease (HD),
motivating the study of transcriptional regulatory networks (TRNs) in HD. We …
motivating the study of transcriptional regulatory networks (TRNs) in HD. We …
Stool is a sensitive and noninvasive source of DNA for monitoring expansion in repeat expansion disease mouse models
Repeat expansion diseases are a large group of human genetic disorders caused by expansion
of a specific short tandem repeat tract. Expansion in somatic cells affects age of onset …
of a specific short tandem repeat tract. Expansion in somatic cells affects age of onset …