Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa (L-dopa)
therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately …

Numerous research has pointed out that serotonin2c (5-HT 2C ) receptor, a subtype of 5-HT
receptors belonging to the G-protein-coupled receptor superfamily, modulates the activity of …

Benefit and motor side effects of l-DOPA in Parkinson's disease have been related to dopamine
transmission in the striatum. However, the putative involvement of serotonergic neurons …

Rationale The influences of the serotonergic system on dopamine (DA) neuron activity have
received considerable attention during the last three decades due to the real opportunity to …

The therapeutic benefit of L-DOPA is commonly attributed to restoration of dopamine (DA)
extracellular levels in the striatum of Parkinsonian patients. However, the loss of efficacy of L-…

High-frequency stimulation of the subthalamic nucleus (STN-HFS) and l-3,4-dihydroxyphenylalanine
(l-DOPA) medication are the most used therapeutic approaches in Parkinson's …

The continuous generation of new neurons in the adult hippocampus exhibits remarkable
plasticity. Decreased neurogenesis is thought to underlie depression‐like behaviors, and …

Stimulation of central serotonin2C receptor (5-HT 2C R) inhibits dopamine (DA)-dependent
neurochemical and behavioral effects of cocaine, while 5-HT 2C Rs locally expressed into …

This chapter brings together the work of several leading laboratories, each an outstanding
example of integrative approaches to complex diseases of the central nervous system. …

During recent years, much attention has been devoted at investigating the modulatory role of
central 5-HT 2C receptors on dopamine (DA) neuron activity, and it has been proposed that …