A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi
and plants are known to be encoded in biosynthetic gene clusters. Information about these …

Analyses of microbial genome sequences reveal numerous examples of gene clusters
encoding proteins typically involved in complex natural product biosynthesis but not associated …

Cyclodipeptides and their derivatives belong to the diketopiperazine (DKP) family, which is
comprised of a broad array of natural products that exhibit useful biological properties. In the …

Albonoursin [cyclo(ΔPhe-ΔLeu)], an antibacterial peptide produced by Streptomyces noursei,
is one of the simplest representatives of the large diketopiperazine (DKP) family. Formation …

Covering: up to 2012 We review here work on the biosynthesis of diketopiperazines (DKPs),
a large class of natural products with noteworthy biological activities, focusing on the …

Siderophore-mediated iron acquisition has been well studied in many bacterial pathogens
because it contributes to virulence. In contrast, siderophore-mediated iron acquisition by …

Nonribosomal peptide synthetases (NRPSs) are giant multi-domain enzymes that catalyse
the biosynthesis of many commercially important peptides produced by bacteria and fungi. …

Since the discovery of the streptomycin produced by Streptomyces griseus in the middle of
the last century, members of this bacterial genus have been largely exploited for the …

MbtH-like proteins are a family of small proteins encoded by genes found in many, but not all,
non-ribosomal peptide synthetase-encoding gene clusters that direct the biosynthesis of …

The synthesis of protein–polymer bioconjugates is reported using N-succinimidyl ester
functionalised polymers from transition metal mediated living radical polymerisation.